Mouse BDNF Standard (小鼠脑源性神经营养因子 (BDNF) 标准品)

BDNF 分子靶点信息概述

• 分子名：BDNF, brain derived neurotrophic factor
• 基因家族：Neurotrophins
• 全称：neurotrophin

BDNF 分子靶点综述

脑源性神经营养因子(BDNF)是生长因子神经营养素家族中的一员，与神经生长因子相关。神经营养因子存在于脑及外周。BDNF在内质网中加工合成，由致密核心囊泡分泌。它在大脑中的海马、皮层和基底前脑区域活跃，同样也在视网膜、运动神经元、肾脏、唾液和前列腺中表达。BDNF作用于中枢神经系统和外周神经系统的某些神经元，帮助现存神经元的存活、促进新生神经元和突触的生长和分化。BDNF的改变可能在精神分裂症的发病中起作用，与抑郁、湿疹、癫痫、阿尔茨海默病、肥胖、衰老、先天性中枢性低通气综合征和化疗后认知功能障碍有关。

小鼠 Mouse Bdnf 分子靶点信息

• 分子名：Bdnf, brain derived neurotrophic factor
• 别称：
  • 无
• 基因序列：NCBI_Gene: 12064
• 蛋白序列：
  • UniprotKB: P21237
  • UniprotKB: E2IUB1
  • UniprotKB: H9H9S8
  • UniprotKB: Q541P3

小鼠 Mouse Bdnf 靶点分子功能（预测）

Predicted to enable growth factor activity; nerve growth factor receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in negative regulation of apoptotic signaling pathway; positive regulation of neuron projection development; and retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission. Acts upstream of or within several processes, including generation of neurons; modulation of chemical synaptic transmission; and sensory organ development. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and secretory granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).