BDNF 靶点信息

BDNF 分子靶点信息概述

  • 分子名：BDNF, brain derived neurotrophic factor
  • 基因家族：Neurotrophins
  • 全称：neurotrophin

BDNF 分子靶点综述

脑源性神经营养因子(BDNF)是生长因子神经营养素家族中的一员，与神经生长因子相关。神经营养因子存在于脑及外周。BDNF在内质网中加工合成，由致密核心囊泡分泌。它在大脑中的海马、皮层和基底前脑区域活跃，同样也在视网膜、运动神经元、肾脏、唾液和前列腺中表达。BDNF作用于中枢神经系统和外周神经系统的某些神经元，帮助现存神经元的存活、促进新生神经元和突触的生长和分化。BDNF的改变可能在精神分裂症的发病中起作用，与抑郁、湿疹、癫痫、阿尔茨海默病、肥胖、衰老、先天性中枢性低通气综合征和化疗后认知功能障碍有关。

BDNF, brain derived neurotrophic factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human BDNF 分子靶点信息

  • 分子名：BDNF, brain derived neurotrophic factor
  • 别称：
    • abrineurin
    • ANON2
    • brain-derived neurotrophic factor
    • BULN2
    • MGC34632
    • neurotrophin
  • 基因序列：NCBI_Gene: 627
  • 蛋白序列：UniProtKB: P23560

人 Human BDNF靶点分子功能（预测）

Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Involved in nervous system development; positive regulation of nervous system development; and positive regulation of receptor binding activity. Located in mitochondrion and nuclear speck. Implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Biomarker of several diseases, including autoimmune disease (multiple); lung disease (multiple); mental depression (multiple); neurodegenerative disease (multiple); and open-angle glaucoma (multiple).

小鼠 Mouse Bdnf 分子靶点信息

小鼠 Mouse Bdnf 靶点分子功能（预测）

Predicted to enable growth factor activity; nerve growth factor receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in negative regulation of apoptotic signaling pathway; positive regulation of neuron projection development; and retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission. Acts upstream of or within several processes, including generation of neurons; modulation of chemical synaptic transmission; and sensory organ development. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and secretory granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).

大鼠 Rat Bdnf 分子靶点信息

大鼠 Rat Bdnf 靶点分子功能（预测）

Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).

BDNF 分子产品列表

BDNF 分子靶点最新资讯

ELISA系列 （6）▏高血压相关热门因子介绍 

ELISA系列 （3）肥胖相关热门因子介绍 

Human TrkB/NTRK2 ELISA试剂盒