Anti-Mouse CD45, PE (Clone:30-F11)流式抗体 (新品)

PTPRC 分子靶点信息概述

• 分子名：PTPRC, protein tyrosine phosphatase receptor type C
• 基因家族：CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type
• 别名：LCA; T200; GP180
• 曾用名：CD45

PTPRC 分子靶点综述

CD45也被称为白细胞共同抗原(leukocyte common antigen, LCA)，由一类结构相似，分子量较大(180 kDa、190 kDa、205 kDa和200 kDa)的跨膜蛋白组成，广泛存在于所有白细胞表面(包括淋巴细胞、粒细胞和单核细胞)，但不表达于成熟的红细胞、血小板、骨髓中的成熟红系细胞以及非造血组织。CD45胞浆区段具有蛋白质酪氨酸磷酸酶的作用，能使底物P56lck和P59fyn上酪氨酸脱磷酸而激活，在细胞的信息传导中发挥重要作用，CD45是细胞膜上信号传导的关键分子，在淋巴细胞的发育成熟，功能调节及信号传递中具有重要意义。CD45的分布可作为某些T细胞亚群的分类标志。

小鼠 Mouse Ptprc 分子靶点信息

• 分子名：Ptprc, protein tyrosine phosphatase, receptor type, C
• 别称：
  • B220
  • CD45
  • Cd45
  • CD45 antigen
  • Ly-5
  • lymphocyte antigen 5
  • Lyt-4
  • T-lymphocyte antigen 4
  • T200
• 基因序列：NCBI_Gene: 19264
• 蛋白序列：
  • UniprotKB: P06800
  • UniprotKB: A0A0A6YWF2
  • UniprotKB: A0A0A6YXM4
  • UniprotKB: A1E2H6
  • UniprotKB: Q05C79
  • UniprotKB: Q3U382
  • UniprotKB: Q5XFY7
  • UniprotKB: Q8C6Q7
  • UniprotKB: S4R1M0

小鼠 Mouse Ptprc 靶点分子功能（预测）

Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).