PTPRC 靶点信息

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PTPRC 分子靶点信息概述

  • 分子名：PTPRC, protein tyrosine phosphatase receptor type C
  • 基因家族：CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type
  • 别名：LCA; T200; GP180
  • 曾用名：CD45

PTPRC 分子靶点综述

CD45也被称为白细胞共同抗原(leukocyte common antigen, LCA)，由一类结构相似，分子量较大(180 kDa、190 kDa、205 kDa和200 kDa)的跨膜蛋白组成，广泛存在于所有白细胞表面(包括淋巴细胞、粒细胞和单核细胞)，但不表达于成熟的红细胞、血小板、骨髓中的成熟红系细胞以及非造血组织。CD45胞浆区段具有蛋白质酪氨酸磷酸酶的作用，能使底物P56lck和P59fyn上酪氨酸脱磷酸而激活，在细胞的信息传导中发挥重要作用，CD45是细胞膜上信号传导的关键分子，在淋巴细胞的发育成熟，功能调节及信号传递中具有重要意义。CD45的分布可作为某些T细胞亚群的分类标志。

PTPRC, protein tyrosine phosphatase receptor type C 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PTPRC 分子靶点信息

  • 分子名：PTPRC, protein tyrosine phosphatase receptor type C
  • 别称：
    • B220
    • CD45
    • CD45 antigen
    • CD45R
    • glycoprotein
    • GP180
    • L-CA
    • LCA
    • leukocyte common antigen
    • leukocyte-common antigen
    • LY5
    • protein tyrosine phosphatase, receptor type, c polypeptide
    • receptor-type tyrosine-protein phosphatase C
    • T200
    • T200 glycoprotein
    • T200 leukocyte common antigen
  • 基因序列：NCBI_Gene: 5788
  • 蛋白序列：UniProtKB: P08575

人 Human PTPRC靶点分子功能（预测）

Enables cytoskeletal protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of cell population proliferation; and regulation of protein kinase activity. Located in bleb and external side of plasma membrane. Implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.

小鼠 Mouse Ptprc 分子靶点信息

小鼠 Mouse Ptprc 靶点分子功能（预测）

Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).

大鼠 Rat Ptprc 分子靶点信息

  • 分子名：Ptprc, protein tyrosine phosphatase, receptor type, C
  • 别称：
    • CD45
    • L-CA
    • Lca
    • leucocyte common antigen
    • leukocyte common antigen
    • leukocyte common antigen A
    • leukocyte common antigen B
    • Protein tyrosine phosphatase, receptor-type, c polypeptide
    • receptor-type tyrosine-protein phosphatase C
    • RT7
    • T200
    • T200 glycoprotein
  • 基因序列：NCBI_Gene: 24699
  • 蛋白序列：UniProtKB: P04157

大鼠 Rat Ptprc 靶点分子功能（预测）

Enables protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).

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