Anti-Mouse CD40, PE (Clone: 01)检测试剂 流式抗体
¥2,264.00
- 分子靶点:CD40/Tnfrsf5
- 种属:小鼠 (Mouse)
- 标记:PE
- 亚型:Rabbit IgG
- 克隆号:01
在售SKU, 70-F2104002-100, F2104002, 70-F2104002-25
描述
文章目录[隐藏]
商品名 |
Anti-Mouse CD40, PE (Clone: 01)检测试剂 流式抗体 |
---|---|
靶点 | |
标记 |
PE |
仪器 |
适用488nm, 532nm, 561nm激光器的流式细胞仪 |
亚型 |
Rabbit IgG |
克隆号 |
01 |
推荐应用 |
流式检测 |
用量 |
5 μL /Test |
纯化 |
亲和层析 |
储存液 |
含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2) |
保存条件 |
2 - 8℃避光,切勿冻存 |
结果示例
图 - 小鼠脾脏细胞染色Anti-Mouse CD40, PE(Clone: 01) (F2104002) 和Anti-Mouse CD19, APC的结果。以全部细胞进行设门。
分子信息
CD40/TNFRSF5 分子靶点信息概述
- 分子名:CD40, CD40 molecule
- 基因家族:CD molecules, Tumor necrosis factor receptor superfamily
- 别名:TNFRSF5
- 全称:tumor necrosis factor receptor superfamily, member 5; CD40 molecule, TNF receptor superfamily member 5
CD40/TNFRSF5 分子靶点综述
CD40是一种48 kDa的I型跨膜糖蛋白,属于肿瘤坏死因子受体(TNFR)超家族。CD40广泛表达于抗原呈递细胞(APCs),如树突状细胞、B细胞、巨噬细胞和单核细胞,以及非免疫内皮细胞、基底上皮细胞和一系列肿瘤。CD40与其配体CD154结合后,作为共刺激分子激活B细胞、树突状细胞、单核细胞和其他APCs。CD40在B细胞活化、分化、增殖和免疫球蛋白同种型转换以及树突状细胞成熟中起作用。
小鼠 Mouse Cd40 分子靶点信息
- 分子名:Cd40, CD40 antigen
- 别称:
- AI326936
- Bp50
- expressed sequence AI326936
- p50
- Tnfrsf5
- tumor necrosis factor receptor superfamily, member 5
- 基因序列:NCBI_Gene: 21939
- 蛋白序列:
小鼠 Mouse Cd40 靶点分子功能(预测)
Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and intracellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).
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