CD40/TNFRSF5 靶点信息

CD40/TNFRSF5 分子靶点信息概述

  • 分子名：CD40, CD40 molecule
  • 基因家族：CD molecules, Tumor necrosis factor receptor superfamily
  • 别名：TNFRSF5
  • 全称：tumor necrosis factor receptor superfamily, member 5; CD40 molecule, TNF receptor superfamily member 5

CD40/TNFRSF5 分子靶点综述

CD40是一种48 kDa的I型跨膜糖蛋白，属于肿瘤坏死因子受体(TNFR)超家族。CD40广泛表达于抗原呈递细胞(APCs)，如树突状细胞、B细胞、巨噬细胞和单核细胞，以及非免疫内皮细胞、基底上皮细胞和一系列肿瘤。CD40与其配体CD154结合后，作为共刺激分子激活B细胞、树突状细胞、单核细胞和其他APCs。CD40在B细胞活化、分化、增殖和免疫球蛋白同种型转换以及树突状细胞成熟中起作用。

CD40/TNFRSF5 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD40 分子靶点信息

  • 分子名：CD40, CD40 molecule
  • 别称：
    • B cell surface antigen CD40
    • B cell-associated molecule
    • B-cell surface antigen CD40
    • Bp50
    • CD40 antigen (TNF receptor superfamily member 5)
    • CD40 molecule TNF receptor superfamily member 5
    • CD40 molecule, TNF receptor superfamily member 5
    • CD40 type II isoform
    • CD40L receptor
    • CDW40
    • MGC9013
    • nerve growth factor receptor-related B-lymphocyte activation molecule
    • p50
    • TNFRSF5
    • tumor necrosis factor receptor superfamily member 5
    • tumor necrosis factor receptor superfamily, member 5
  • 基因序列：NCBI_Gene: 958
  • 蛋白序列：UniProtKB: P25942

人 Human CD40 靶点分子功能（预测）

Enables ubiquitin protein ligase binding activity. Involved in several processes, including CD40 signaling pathway; positive regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Located in cell surface and extracellular exosome. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bronchial disease (multiple); cardiomyopathy (multiple); and hematologic cancer (multiple).

小鼠 Mouse Cd40 分子靶点信息

小鼠 Mouse Cd40 靶点分子功能（预测）

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and intracellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).

大鼠 Rat Cd40 分子靶点信息

大鼠 Rat Cd40 靶点分子功能（预测）

Enables antigen binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to cobalamin; and response to type II interferon. Located in several cellular components, including cell surface; neuronal cell body; and varicosity. Used to study several diseases, including Ehrlich tumor carcinoma; artery disease (multiple); colitis; membranous glomerulonephritis; and obesity. Biomarker of asthma; atherosclerosis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).

CD40/TNFRSF5 分子产品列表

CD40/TNFRSF5 分子靶点最新资讯

ELISA系列丨肿瘤坏死因子TNF配体及受体超家族成员 

天气很冷，这些靶标却很“热”！ 

新品发布 ▏深秋的第一波流式抗体，快来了解！ 

免疫检查点Immune checkpoints —抗体和蛋白