Anti-Mouse CD40, APC （Clone: 01）检测试剂 流式抗体

CD40/TNFRSF5 分子靶点信息概述

• 分子名：CD40, CD40 molecule
• 基因家族：CD molecules, Tumor necrosis factor receptor superfamily
• 别名：TNFRSF5
• 全称：tumor necrosis factor receptor superfamily, member 5; CD40 molecule, TNF receptor superfamily member 5

CD40/TNFRSF5 分子靶点综述

CD40是一种48 kDa的I型跨膜糖蛋白，属于肿瘤坏死因子受体(TNFR)超家族。CD40广泛表达于抗原呈递细胞(APCs)，如树突状细胞、B细胞、巨噬细胞和单核细胞，以及非免疫内皮细胞、基底上皮细胞和一系列肿瘤。CD40与其配体CD154结合后，作为共刺激分子激活B细胞、树突状细胞、单核细胞和其他APCs。CD40在B细胞活化、分化、增殖和免疫球蛋白同种型转换以及树突状细胞成熟中起作用。

小鼠 Mouse Cd40 分子靶点信息

• 分子名：Cd40, CD40 antigen
• 别称：
  • AI326936
  • Bp50
  • expressed sequence AI326936
  • p50
  • Tnfrsf5
  • tumor necrosis factor receptor superfamily, member 5
• 基因序列：NCBI_Gene: 21939
• 蛋白序列：
  • UniprotKB: A2A5L7
  • UniprotKB: P27512
  • UniprotKB: S4R2M8

小鼠 Mouse Cd40 靶点分子功能（预测）

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and intracellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).