Anti-Mouse CD4, mFluor 540 Clone: GK1.5流式抗体 (新品)

CD4 分子靶点信息概述

• 分子名：CD4, CD4 molecule
• 基因家族：CD molecules; V-set domain containing; C2-set domain containing
• 全称：CD4 antigen (p55); T-cell surface glycoprotein CD4

CD4 分子靶点综述

克隆号GK1.5单克隆抗体能与小鼠CD4反应。CD4抗原是属于免疫球蛋白超家族的55 kDa细胞表面I型膜糖蛋白 。CD4作为一种共受体，与T细胞受体(TCR)合作，与抗原呈递细胞(APC)的class II MHC分子相互作用。大多数胸腺细胞、大多数辅助性T细胞、NK-T细胞的一个亚群表达CD4 ，树突状细胞和巨噬细胞表达较少。CD4在T细胞的发育中起着重要作用，是成熟T细胞发挥最佳功能所必需的。克隆号GK1.5抗体已被证明与克隆号YTS 177和YTS 191竞争CD4的结合。

小鼠 Mouse Cd4 分子靶点信息

• 分子名：Cd4, CD4 antigen
• 别称：
  • L3T4
  • Ly-4
  • lymphocyte antigen 4
• 基因序列：NCBI_Gene: 12504
• 蛋白序列：
  • UniprotKB: P06332
  • UniprotKB: O55054
  • UniprotKB: P70443
  • UniprotKB: Q3TSV7

小鼠 Mouse Cd4 靶点分子功能（预测）

Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).