CD4 靶点信息

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CD4 分子靶点信息概述

  • 分子名：CD4, CD4 molecule
  • 基因家族：CD molecules; V-set domain containing; C2-set domain containing
  • 全称：CD4 antigen (p55); T-cell surface glycoprotein CD4

CD4 分子靶点综述

CD4也称为T4，为55 kD的单链I型跨膜糖蛋白，表达于大部分胸腺细胞、T细胞亚群和单核/巨噬细胞。CD4作为免疫球蛋白超家族的一员，可识别与MHC II类分子结合的抗原，参与细胞-细胞互作、胸腺分化和信号传导。CD4是HIV的主要受体，可与HIV gp120结合。CD4与IL-16也有相互作用。

CD4, CD4 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD4 分子靶点信息

  • 分子名：CD4, CD4 molecule
  • 别称：
    • cd4 antigen
    • CD4 antigen (p55)
    • CD4 receptor
    • CD4mut
    • IMD79
    • OKT4D
    • T-cell surface antigen T4/Leu-3
    • T-cell surface glycoprotein CD4
  • 基因序列：NCBI_Gene: 920
  • 蛋白序列：UniProtKB: P01730

人 Human CD4靶点分子功能（预测）

Enables several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte differentiation; and positive regulation of intracellular signal transduction. Acts upstream of or within maintenance of protein location in cell. Located in external side of plasma membrane and membrane raft. Is integral component of plasma membrane. Implicated in immunodeficiency 79. Biomarker of COVID-19 and severe acute respiratory syndrome.

小鼠 Mouse Cd4 分子靶点信息

小鼠 Mouse Cd4 靶点分子功能（预测）

Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).

大鼠 Rat Cd4 分子靶点信息

  • 分子名：Cd4, Cd4 molecule
  • 别称：
    • CD4 antigen
    • CD4 antigen (p55)
    • p55
    • T-cell surface antigen T4/Leu-3
    • T-cell surface glycoprotein CD4
    • W3/25
    • W3/25 antigen
  • 基因序列：NCBI_Gene: 24932
  • 蛋白序列：UniProtKB: P05540

大鼠 Rat Cd4 靶点分子功能（预测）

Enables immunoglobulin binding activity; protein tyrosine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of calcium ion transport into cytosol; response to estradiol; and response to vitamin D. Located in external side of plasma membrane. Used to study septic arthritis and sialadenitis. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).

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