Anti-Mouse CD1d, APC(Clone: 20H2) 检测试剂

CD1D 分子靶点信息概述

• 分子名：CD1D, CD1d molecule
• 全称：CD1D antigen, d polypeptide; CD1d antigen

CD1D 分子靶点综述

CD1d是group 2 CD1 molecules的唯一成员。该家族在结构上与主要组织相容性复合体（MHC）蛋白相关，并与β-2-微球蛋白形成异二聚体。CD1蛋白介导自身或微生物来源的主要脂质和糖脂抗原向T细胞的呈递。CD1d基因编码的蛋白质通过细胞质尾部的酪氨酸基序定位于晚期内体和溶酶体。与CD1D相关的疾病包括马尔默分枝杆菌和自身免疫性疾病。

小鼠 Mouse Cd1d1 分子靶点信息

• 分子名：Cd1d1, CD1d1 antigen
• 别称：
  • AI747460
  • CD1.1
  • Cd1a
  • CD1a antigen
  • Cd1d
  • CD1d antigen
  • expressed sequence AI747460
  • Ly-38
  • lymphocyte antigen 38
• 基因序列：NCBI_Gene: 12479
• 蛋白序列：
  • UniprotKB: A0A0R4J090
  • UniprotKB: B9VQY2
  • UniprotKB: E9Q395
  • UniprotKB: P11609
  • UniprotKB: Q7TMK5

小鼠 Mouse Cd1d1 靶点分子功能（预测）

Enables T cell receptor binding activity and endogenous lipid antigen binding activity. Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of cytokine production; and positive regulation of leukocyte activation. Located in endosome; external side of plasma membrane; and lysosome. Is expressed in forebrain; intestine; jaw bone; and liver. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1D (CD1d molecule).