CD1D 靶点信息

CD1D 分子靶点信息概述

  • 分子名：CD1D, CD1d molecule
  • 全称：CD1D antigen, d polypeptide; CD1d antigen

CD1D 分子靶点综述

CD1d是group 2 CD1 molecules的唯一成员。该家族在结构上与主要组织相容性复合体（MHC）蛋白相关，并与β-2-微球蛋白形成异二聚体。CD1蛋白介导自身或微生物来源的主要脂质和糖脂抗原向T细胞的呈递。CD1d基因编码的蛋白质通过细胞质尾部的酪氨酸基序定位于晚期内体和溶酶体。与CD1D相关的疾病包括马尔默分枝杆菌和自身免疫性疾病。

CD1D, CD1D molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD300E 分子靶点信息

  • 分子名：CD1D, CD1D molecule
  • 别称：
    • antigen-presenting glycoprotein CD1d
    • CD1A
    • CD1D antigen, d polypeptide
    • differentiation antigen CD1-alpha-3
    • HMC class I antigen-like glycoprotein CD1D
    • MGC34622
    • R3
    • R3G1
    • T-cell surface glycoprotein CD1d
    • thymocyte antigen CD1D
  • 基因序列：NCBI_Gene: 912
  • 蛋白序列：UniProtKB: P15813

人 Human CD1D 靶点分子功能（预测）

Enables cell adhesion molecule binding activity; exogenous lipid antigen binding activity; and histone binding activity. Involved in antigen processing and presentation, endogenous lipid antigen via MHC class Ib and positive regulation of T cell proliferation. Located in cell surface; endoplasmic reticulum; and lysosome. Implicated in pulmonary tuberculosis. Biomarker of dengue hemorrhagic fever; stomach cancer; and urinary schistosomiasis.

小鼠 Mouse Cd1d1 分子靶点信息

小鼠 Mouse Cd1d1 靶点分子功能（预测）

Enables T cell receptor binding activity and endogenous lipid antigen binding activity. Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of cytokine production; and positive regulation of leukocyte activation. Located in endosome; external side of plasma membrane; and lysosome. Is expressed in forebrain; intestine; jaw bone; and liver. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1D (CD1d molecule).

大鼠 Rat Cd300e 分子靶点信息

  • 分子名：Cd1d1, Cd1d1 molecule
  • 别称：
    • antigen-presenting glycoprotein CD1d
    • Cd1
    • Cd1d
    • CD1D antigen
    • CD1D antigen also localized to RNO7q32 but is presumably on chromosome 2
    • CD1d1 antigen
    • T-cell surface glycoprotein CD1d
  • 基因序列：NCBI_Gene: 25109
  • 蛋白序列：

大鼠 Rat Cd300e 靶点分子功能（预测）

Predicted to enable several functions, including T cell receptor binding activity; lipid antigen binding activity; and lipopeptide binding activity. Predicted to be involved in several processes, including antigen processing and presentation, endogenous lipid antigen via MHC class Ib; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; and regulation of T cell proliferation. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of leukocyte activation; and positive thymic T cell selection. Predicted to be located in several cellular components, including cell surface; endosome; and lysosome. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1D (CD1d molecule).

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