Anti-Human CD62P, FITC (Clone:AK-4) (新品)

SELP 分子靶点信息概述

• 分子名：SELP, selectin P
• 基因家族：CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
• 别名：CD62; PSEL; PADGEM; GMP140; CD62P
• 曾用名：GRMP
• 全称：antigen CD62; granule membrane protein 140kDa; selectin P (granule membrane protein 140kD, antigen CD62); selectin P (granule membrane protein 140kDa, antigen CD62)

SELP 分子靶点综述

CD62P 是一种 140kDa 跨膜糖蛋白，也称为 P-Selectin。P-Selectin被储存在血小板的 α 颗粒和内皮细胞的 Weibel-Palade 小体中，并在激活后迅速转运到质膜。在炎症反应中，P-Selectin 被认为介导中性粒细胞和单核细胞与内皮的初始粘附相互作用；在止血过程中，活化的血小板与中性粒细胞和单核细胞相互作用。

人 Human SELP 分子靶点信息

• 分子名：SELP, selectin P
• 别称：
  • CD62
  • CD62 antigen-like family member P
  • CD62P
  • FLJ45155
  • GMP-140
  • GMP140
  • granule membrane protein 140
  • granule membrane protein 140kDa
  • granulocyte membrane protein
  • GRMP
  • LECAM3
  • leukocyte-endothelial cell adhesion molecule 3
  • P-selectin
  • PADGEM
  • platelet activation dependent granule-external membrane protein
  • platelet alpha-granule membrane protein
  • PSEL
  • selectin P (granule membrane protein 140kDa, antigen CD62)
• 基因序列：NCBI_Gene: 6403
• 蛋白序列：UniProtKB: P16109

人 Human SELP靶点分子功能（预测）

Enables several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; and leukocyte tethering or rolling. Located in external side of plasma membrane; extracellular space; and platelet alpha granule membrane. Is integral component of plasma membrane. Implicated in atopic dermatitis and myocardial infarction. Biomarker of several diseases, including Kawasaki disease; autoimmune disease (multiple); coronary artery disease (multiple); obesity; and type 2 diabetes mellitus.