SELP 靶点信息

SELP 分子靶点信息概述

  • 分子名：SELP, selectin P
  • 基因家族：CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
  • 别名：CD62; PSEL; PADGEM; GMP140; CD62P
  • 曾用名：GRMP
  • 全称：antigen CD62; granule membrane protein 140kDa; selectin P (granule membrane protein 140kD, antigen CD62); selectin P (granule membrane protein 140kDa, antigen CD62)

SELP 分子靶点综述

CD62P 是一种 140kDa 跨膜糖蛋白，也称为 P-Selectin。P-Selectin被储存在血小板的 α 颗粒和内皮细胞的 Weibel-Palade 小体中，并在激活后迅速转运到质膜。在炎症反应中，P-Selectin 被认为介导中性粒细胞和单核细胞与内皮的初始粘附相互作用；在止血过程中，活化的血小板与中性粒细胞和单核细胞相互作用。

SELP, selectin P 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SELP 分子靶点信息

  • 分子名：SELP, selectin P
  • 别称：
    • CD62
    • CD62 antigen-like family member P
    • CD62P
    • FLJ45155
    • GMP-140
    • GMP140
    • granule membrane protein 140
    • granule membrane protein 140kDa
    • granulocyte membrane protein
    • GRMP
    • LECAM3
    • leukocyte-endothelial cell adhesion molecule 3
    • P-selectin
    • PADGEM
    • platelet activation dependent granule-external membrane protein
    • platelet alpha-granule membrane protein
    • PSEL
    • selectin P (granule membrane protein 140kDa, antigen CD62)
  • 基因序列：NCBI_Gene: 6403
  • 蛋白序列：UniProtKB: P16109

人 Human SELP靶点分子功能（预测）

Enables several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-mediated signaling using intracellular calcium source; and leukocyte tethering or rolling. Located in external side of plasma membrane; extracellular space; and platelet alpha granule membrane. Is integral component of plasma membrane. Implicated in atopic dermatitis and myocardial infarction. Biomarker of several diseases, including Kawasaki disease; autoimmune disease (multiple); coronary artery disease (multiple); obesity; and type 2 diabetes mellitus.

小鼠 Mouse Selp 分子靶点信息

小鼠 Mouse Selp 靶点分子功能（预测）

Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).

大鼠 Rat Selp 分子靶点信息

大鼠 Rat Selp 靶点分子功能（预测）

Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P).

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