Anti-Human CD11c, APC (Clone:3.9)检测试剂

ITGAX 分子靶点信息概述

• 分子名：ITGAX, integrin subunit alpha X
• 基因家族：CD molecules; Integrin alpha subunits; Complement system regulators and receptors
• 别名：CD11c
• 曾用名：CD11C
• 全称：complement component 3 receptor 4 subunit; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit)

ITGAX 分子靶点综述

CD11c被称为补体受体4 (Complement receptor, CR4)，是黏附分子CD11/CD18家族中的一员，属于I型跨膜糖蛋白，高表达于髓系DCs表面。CD11c作为一正性调控因子，参与DCs的黏附、迁移，抗原的识别和呈递，并激活CD4+、CD8+ T细胞，调控免疫应答发生，在感染和抗肿瘤免疫中发挥重要作用。

人 Human ITGAX 分子靶点信息

• 分子名：ITGAX, integrin subunit alpha X
• 别称：
  • CD11 antigen-like family member C
  • CD11C
  • complement component 3 receptor 4 subunit
  • integrin alpha X
  • integrin alpha-X
  • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
  • integrin, alpha X (complement component 3 receptor 4 subunit)
  • leu M5, alpha subunit
  • leukocyte adhesion glycoprotein p150,95 alpha chain
  • leukocyte adhesion receptor p150,95
  • leukocyte surface antigen p150,95, alpha subunit
  • myeloid membrane antigen, alpha subunit
  • p150 95 integrin alpha chain
  • SLEB6
• 基因序列：NCBI_Gene: 3687
• 蛋白序列：UniProtKB: P20702

人 Human ITGAX靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial tube morphogenesis. Located in cell surface.