ITGAX 靶点信息

ITGAX 分子靶点信息概述

  • 分子名：ITGAX, integrin subunit alpha X
  • 基因家族：CD molecules; Integrin alpha subunits; Complement system regulators and receptors
  • 别名：CD11c
  • 曾用名：CD11C
  • 全称：complement component 3 receptor 4 subunit; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit)

ITGAX 分子靶点综述

CD11c被称为补体受体4 (Complement receptor, CR4)，是黏附分子CD11/CD18家族中的一员，属于I型跨膜糖蛋白，高表达于髓系DCs表面。CD11c作为一正性调控因子，参与DCs的黏附、迁移，抗原的识别和呈递，并激活CD4+、CD8+T细胞，调控免疫应答发生，在感染和抗肿瘤免疫中发挥重要作用。

ITGAX, integrin subunit alpha X 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ITGAX 分子靶点信息

  • 分子名：ITGAX, integrin subunit alpha X
  • 别称：
    • CD11 antigen-like family member C
    • CD11C
    • complement component 3 receptor 4 subunit
    • integrin alpha X
    • integrin alpha-X
    • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
    • integrin, alpha X (complement component 3 receptor 4 subunit)
    • leu M5, alpha subunit
    • leukocyte adhesion glycoprotein p150,95 alpha chain
    • leukocyte adhesion receptor p150,95
    • leukocyte surface antigen p150,95, alpha subunit
    • myeloid membrane antigen, alpha subunit
    • p150 95 integrin alpha chain
    • SLEB6
  • 基因序列：NCBI_Gene: 3687
  • 蛋白序列：UniProtKB: P20702

人 Human ITGAX靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial tube morphogenesis. Located in cell surface.

小鼠 Mouse Itgax 分子靶点信息

小鼠 Mouse Itgax 靶点分子功能（预测）

Predicted to enable receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X).

大鼠 Rat Itgax 分子靶点信息

大鼠 Rat Itgax 靶点分子功能（预测）

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin complex. Orthologous to human ITGAX (integrin subunit alpha X).

ITGAX 分子产品列表

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