Anti-Human CD10, APC (Clone:SN5c) (新品)

MME 分子靶点信息概述

• 分子名：MME, membrane metalloendopeptidase
• 基因家族：CD molecules; M13 metallopeptidases
• 别名：CALLA; CD10; NEP
• 全称：neutral endopeptidase; enkephalinase; neprilysin

MME 分子靶点综述

CD10 是 100 kDa 的 II 型跨膜蛋白，CD10 抗原又称普通急性淋巴细胞白血病抗原(CALLA)、中性内肽酶(NEP)、gp100 和脑啡肽酶。正常情况下，它在早期 B 和 T 淋巴样前体、中性粒细胞和各种上皮细胞表面上表达。CD10 在急性淋巴母细胞和滤泡生发中心淋巴瘤等淋巴瘤细胞中也有表达。CD10 是一种内肽酶，参与 B 细胞的发育，也是中性粒细胞炎症反应的介质。

人 Human MME 分子靶点信息

• 分子名：MME, membrane metalloendopeptidase
• 别称：
  • atriopeptidase
  • CALLA
  • CD10
  • CMT2T
  • common acute lymphocytic leukemia antigen
  • DKFZp686O16152
  • enkephalinase
  • membrane metallo endopeptidase
  • membrane metallo-endopeptidase
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
  • membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
  • membrane metallo-endopeptidase variant 1
  • membrane metallo-endopeptidase variant 2
  • MGC126681
  • MGC126707
  • NEP
  • neprilysin
  • neprilysin-390
  • neprilysin-411
  • neutral endopeptidase 24.11
  • SCA43
  • SFE
  • skin fibroblast elastase
• 基因序列：NCBI_Gene: 4311
• 蛋白序列：UniProtKB: P08473

人 Human MME靶点分子功能（预测）

Enables several functions, including peptidase activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; cellular response to UV; and neuropeptide processing. Located in several cellular components, including brush border; early endosome; and trans-Golgi network. Implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Biomarker of cerebral amyloid angiopathy and periodontitis.