文章目录[隐藏]
MME 分子靶点信息概述
- 分子名：MME, membrane metalloendopeptidase
- 基因家族：CD molecules; M13 metallopeptidases
- 别名：CALLA; CD10; NEP
- 全称：neutral endopeptidase; enkephalinase; neprilysin
MME 分子靶点综述
CD10 是 100 kDa 的 II 型跨膜蛋白，CD10 抗原又称普通急性淋巴细胞白血病抗原(CALLA)、中性内肽酶(NEP)、gp100 和脑啡肽酶。正常情况下，它在早期 B 和 T 淋巴样前体、中性粒细胞和各种上皮细胞表面上表达。CD10 在急性淋巴母细胞和滤泡生发中心淋巴瘤等淋巴瘤细胞中也有表达。CD10 是一种内肽酶，参与 B 细胞的发育，也是中性粒细胞炎症反应的介质。
MME, membrane metalloendopeptidase 分子靶点种属信息
人 Human MME 分子靶点信息
- 分子名：MME, membrane metalloendopeptidase
- 别称：
- atriopeptidase
- CALLA
- CD10
- CMT2T
- common acute lymphocytic leukemia antigen
- DKFZp686O16152
- enkephalinase
- membrane metallo endopeptidase
- membrane metallo-endopeptidase
- membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
- membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
- membrane metallo-endopeptidase variant 1
- membrane metallo-endopeptidase variant 2
- MGC126681
- MGC126707
- NEP
- neprilysin
- neprilysin-390
- neprilysin-411
- neutral endopeptidase 24.11
- SCA43
- SFE
- skin fibroblast elastase
- 基因序列：NCBI_Gene: 4311
- 蛋白序列：UniProtKB: P08473
人 Human MME靶点分子功能（预测）
Enables several functions, including peptidase activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; cellular response to UV; and neuropeptide processing. Located in several cellular components, including brush border; early endosome; and trans-Golgi network. Implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Biomarker of cerebral amyloid angiopathy and periodontitis.
小鼠 Mouse Pdcd10 分子靶点信息
- 分子名：Pdcd10, programmed cell death 10
- 别称：
- 2410003B13Rik
- CCM3
- RIKEN cDNA 2410003B13 gene
- TF-1 cell apoptosis related protein-15
- Tfa15
- 基因序列：NCBI_Gene: 56426
- 蛋白序列：
小鼠 Mouse Pdcd10 靶点分子功能（预测）
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in Golgi apparatus. Is expressed in several structures, including cardiovascular system; central nervous system; gut; retina layer; and umbilical artery. Used to study cerebral cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).
大鼠 Rat Pdcd10 分子靶点信息
- 分子名：Pdcd10, programmed cell death 10
- 别称：
- MGC72992
- programmed cell death protein 10
- similar to programmed cell death 10
- 基因序列：NCBI_Gene: 494345
- 蛋白序列：UniProtKB: Q6NX65
大鼠 Rat Pdcd10 靶点分子功能（预测）
Predicted to enable protein N-terminus binding activity; protein homodimerization activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of cell migration. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).
MME 分子产品列表
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- F1101003
- 流式抗体（新品）
Anti-Human CD10, APC (Clone:SN5c) (新品)
- ¥792.00 – ¥1,760.00
