P1F03

Recombinant Human FGF-basic (154 a.a.)

¥300.00 – ¥2,850.00

说明书

分子靶点：FGF2, FGFB
种属：人 (Human)
表达宿主：Escherichia coli
纯度：≥95% as determined by SDS-PAGE
内毒素：<1EU/ug

在售SKU: P1F03, 70-P1F03-25, 70-P1F03-250, 70-P1F03-5, 70-P1F03-50, 70-P1F03-96

描述

文章目录[隐藏]

General Information
Specifications
Data
分子信息
FGF2 分子靶点信息概述
FGF2 分子靶点综述
- 人 Human FGF2 分子靶点信息
- 人 Human FGF2靶点分子功能（预测）

General Information

Source	Escherichia coli
Synonyms	Fibroblast Growth Factor 2; FGF-2; Basic Fibroblast Growth Factor; bFGF; HeparinBinding Growth Factor 2; HBGF-2; FGF2; FGFB
Accession	P09038
Molecular Mass	17.2 KDa
Description	Recombinant Human Fibroblast Growth Factor 2/Fibroblast Growth Factor Basic is produced by our E.coli expression system and the target gene encoding Ala135-Ser288 is expressed
Shipping	The product is shipped at 4 ℃ . Upon receipt, store it immediately at the temperature recommended below
Stability & Storage	Aliquot the reconstituted solution to minimize freeze-thaw cycles. Lyophilized protein should be stored at -20℃ to -80℃, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months
Reconstitution	Centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Do not mix by vortex. It is recommended to dissolve the product at a concentration of twice the specified specification
Background	FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells

Specifications

Formulation	Lyophilized from sterile PBS, pH 7.4, 5% trehalose.
Purity	≥95% as determined by SDS-PAGE
Endotoxin	<1EU/ug
Bio Activity	Measured in a cell proliferation assay using NIH-3T3 cells.The ED50 for this effects is 0.09409 ng/ml

Data

Greater than 95% as determined by reducing SDS-PAGE

Bioactivity — Measured in a cell proliferation assay using NIH-3T3 cells.The ED50 for this effects is 0.09409 ng/ml

分子信息

概述人 FGF2, FGFB 靶点信息

FGF2 分子靶点信息概述

分子名：FGF2, fibroblast growth factor 2
基因家族：Receptor ligands; Fibroblast growth factor family
曾用名：FGFB
全称：fibroblast growth factor 2 (basic)

FGF2 分子靶点综述

碱性成纤维细胞生长因子(FGFbasic)，又名bFGF、FGF2或FGF-β，是成纤维细胞生长因子家族中的一员。在正常组织的伤口愈合和肿瘤发展过程中，硫酸乙酰肝素降解酶激活FGFbasic来介导血管生成。另外，人类脂肪细胞可合成和分泌FGFbasic，它的浓度和血液样本中的BMI相关。研究显示低水平的FGFbasic在过度焦虑的发生中发挥重要作用。此外，FGFbasic是人类胚胎干细胞培养基中的重要组成成分，是维持细胞未分化状态的必要因素。FGFbasic与BMP4一起可促进干细胞分化为中胚层谱系。相比于未处理的干细胞，经BMP4和FGFbasic处理过的干细胞通常会分化出更多的成骨细胞和软骨细胞。

人 Human FGF2 分子靶点信息

分子名：FGF2, fibroblast growth factor 2
别称：
- basic fibroblast growth factor bFGF
- BFGF
- FGF-2
- FGFB
- fibroblast growth factor 2 (basic)
- HBGF-2
- heparin-binding growth factor 2
- prostatropin
基因序列：NCBI_Gene: 2247
蛋白序列：UniProtKB: P09038

人 Human FGF2靶点分子功能（预测）

Enables several functions, including identical protein binding activity; nuclear receptor coactivator activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Acts upstream of or within positive regulation of cell fate specification and positive regulation of cell population proliferation. Located in extracellular space. Implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).