FGF2 靶点信息

FGF2 分子靶点信息概述

  • 分子名：FGF2, fibroblast growth factor 2
  • 基因家族：Receptor ligands; Fibroblast growth factor family
  • 曾用名：FGFB
  • 全称：fibroblast growth factor 2 (basic)

FGF2 分子靶点综述

碱性成纤维细胞生长因子(FGFbasic)，又名bFGF、FGF2或FGF-β，是成纤维细胞生长因子家族中的一员。在正常组织的伤口愈合和肿瘤发展过程中，硫酸乙酰肝素降解酶激活FGFbasic来介导血管生成。另外，人类脂肪细胞可合成和分泌FGFbasic，它的浓度和血液样本中的BMI相关。研究显示低水平的FGFbasic在过度焦虑的发生中发挥重要作用。此外，FGFbasic是人类胚胎干细胞培养基中的重要组成成分，是维持细胞未分化状态的必要因素。FGFbasic与BMP4一起可促进干细胞分化为中胚层谱系。相比于未处理的干细胞，经BMP4和FGFbasic处理过的干细胞通常会分化出更多的成骨细胞和软骨细胞。

FGF2, fibroblast growth factor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGF2 分子靶点信息

  • 分子名：FGF2, fibroblast growth factor 2
  • 别称：
    • basic fibroblast growth factor bFGF
    • BFGF
    • FGF-2
    • FGFB
    • fibroblast growth factor 2 (basic)
    • HBGF-2
    • heparin-binding growth factor 2
    • prostatropin
  • 基因序列：NCBI_Gene: 2247
  • 蛋白序列：UniProtKB: P09038

人 Human FGF2靶点分子功能（预测）

Enables several functions, including identical protein binding activity; nuclear receptor coactivator activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Acts upstream of or within positive regulation of cell fate specification and positive regulation of cell population proliferation. Located in extracellular space. Implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).

小鼠 Mouse Fgf2 分子靶点信息

小鼠 Mouse Fgf2 靶点分子功能（预测）

Enables growth factor activity. Involved in stem cell development. Acts upstream of or within several processes, including animal organ development; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2).

大鼠 Rat Fgf2 分子靶点信息

大鼠 Rat Fgf2 靶点分子功能（预测）

Enables fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis involved in coronary vascular morphogenesis; paracrine signaling; and positive regulation of cell population proliferation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in cytoplasm; extracellular space; and nucleus. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2).

FGF2 分子产品列表

FGF2 靶点ELISA产品列表

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FGF2 靶点重组蛋白产品列表

FGF2 分子靶点最新资讯

FGF basic/FGF2/bFGF：细胞培养中必不可少的生长因子 

新品速递 | Mouse FGF basic/FGF2/bFGF ELISA Kit 

PeproTech hESC与hiPSCs维持培养基