Mouse VEGF R2/FIK-1 Standard (小鼠血管内皮生长因子受体2 标准品)

KDR 分子靶点信息概述

• 分子名：KDR, kinase insert domain receptor
• 基因家族：Receptor tyrosine kinases; CD molecules; V-set domain containing; I-set domain containing
• 别名：FLK1; VEGFR; VEGFR2; CD309
• 全称：vascular endothelial growth factor receptor 2; fetal liver kinase 1; kinase insert domain receptor (a type III receptor tyrosine kinase)

KDR 分子靶点综述

血管内皮生长因子受体2(VEGFR2)也称为激酶插入区受体(KDR)，是酪氨酸激酶受体(RTKs)III类亚家族成员。与VEGFR1相比，VEGFR2更广泛分布表达于说要血管衍生的内皮细胞。VEGFR2与VEGF-A(VEGF121、VEGF165、VEGF189和VEGF206剪切变体)、VEGF-C和VEGF-D结合。可溶性VEGFR1和VEGFR2在阻断VEGF诱导的细胞增殖和迁移方面差异非常显著。可溶性VEGFR2与可溶性VEGFR1相反，它无法与VEGF竞争，与表达VEGFR1和VEGFR2的内皮细胞结合。可溶性VEGFR2只能部分抑制细胞迁移，而可溶性VEGFR1几乎完全阻断VEGF诱导的细胞增殖和迁移。VEGF与可溶性VEGFR2而非VEGFR1的结合也依赖于肝素。VEGF/VEGFR2信号通路在肿瘤发生和其它病理性血管发生的疾病中具有重要作用。利用阻断抗体使功能性VEGFR2功能失活可破坏血管生成，阻止肿瘤细胞扩散。

小鼠 Mouse Kdr 分子靶点信息

• 分子名：Kdr, kinase insert domain protein receptor
• 别称：
  • fetal liver kinase 1
  • Flk-1
  • Flk1
  • orv
  • orvieto
  • vascular endothelial growth factor receptor- 2
  • VEGF receptor-2
  • VEGFR-2
  • VEGFR2
• 基因序列：NCBI_Gene: 16542
• 蛋白序列：
  • UniprotKB: P35918
  • UniprotKB: Q3UQZ6
  • UniprotKB: Q8CD05

小鼠 Mouse Kdr 靶点分子功能（预测）

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).