KDR 靶点信息

KDR 分子靶点信息概述

  • 分子名：KDR, kinase insert domain receptor
  • 基因家族：Receptor tyrosine kinases; CD molecules; V-set domain containing; I-set domain containing
  • 别名：FLK1; VEGFR; VEGFR2; CD309
  • 全称：vascular endothelial growth factor receptor 2; fetal liver kinase 1; kinase insert domain receptor (a type III receptor tyrosine kinase)

KDR 分子靶点综述

血管内皮生长因子受体2(VEGFR2)也称为激酶插入区受体(KDR)，是酪氨酸激酶受体(RTKs)III类亚家族成员。与VEGFR1相比，VEGFR2更广泛分布表达于说要血管衍生的内皮细胞。VEGFR2与VEGF-A(VEGF121、VEGF165、VEGF189和VEGF206剪切变体)、VEGF-C和VEGF-D结合。可溶性VEGFR1和VEGFR2在阻断VEGF诱导的细胞增殖和迁移方面差异非常显著。可溶性VEGFR2与可溶性VEGFR1相反，它无法与VEGF竞争，与表达VEGFR1和VEGFR2的内皮细胞结合。可溶性VEGFR2只能部分抑制细胞迁移，而可溶性VEGFR1几乎完全阻断VEGF诱导的细胞增殖和迁移。VEGF与可溶性VEGFR2而非VEGFR1的结合也依赖于肝素。VEGF/VEGFR2信号通路在肿瘤发生和其它病理性血管发生的疾病中具有重要作用。利用阻断抗体使功能性VEGFR2功能失活可破坏血管生成，阻止肿瘤细胞扩散。

KDR, kinase insert domain receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human KDR 分子靶点信息

  • 分子名：KDR, kinase insert domain receptor
  • 别称：
    • CD309
    • fetal liver kinase 1
    • fetal liver kinase-1
    • FLK1
    • kinase insert domain receptor (a type III receptor tyrosine kinase)
    • protein-tyrosine kinase receptor Flk-1
    • soluble VEGFR2
    • tyrosine kinase growth factor receptor
    • vascular endothelial growth factor receptor 2
    • VEGFR
    • VEGFR2
  • 基因序列：NCBI_Gene: 3791
  • 蛋白序列：UniProtKB: P35968

人 Human KDR靶点分子功能（预测）

Enables several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including intracellular signal transduction; positive regulation of endothelial cell migration; and protein phosphorylation. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); cerebrovascular disease (multiple); eye disease (multiple); and systemic scleroderma (multiple).

小鼠 Mouse Kdr 分子靶点信息

小鼠 Mouse Kdr 靶点分子功能（预测）

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).

大鼠 Rat Kdr 分子靶点信息

  • 分子名：Kdr, kinase insert domain receptor
  • 别称：
    • fetal liver kinase 1
    • FLK-1
    • FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
    • FLK1 kinase insert domain receptor (VEGF receptor 2)
    • kinase insert domain protein receptor
    • MGC93590
    • protein-tyrosine kinase receptor flk-1
    • vascular endothelial growth factor receptor 2
    • Vegfr-2
  • 基因序列：NCBI_Gene: 25589
  • 蛋白序列：

大鼠 Rat Kdr 靶点分子功能（预测）

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; positive regulation of endothelial cell proliferation; and positive regulation of intracellular signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and plasma membrane. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor).

KDR 分子产品列表

KDR 分子靶点最新资讯

ELISA系列 | 血管内皮生长因子（VEGF）