Mouse TSLP Standard (小鼠胸腺基质淋巴细胞生成素 (TSLP) 标准品)
¥180.00
描述
文章目录[隐藏]
本产品只包含标准品试剂，如需购买试剂盒请点击下图
| 商品名 |
Mouse TSLP Standard (小鼠胸腺基质淋巴细胞生成素 (TSLP) 标准品) |
|---|---|
| 组分 |
小鼠VEGF R1/Flt-1 标准品 |
| 检测方法 |
双抗夹心法 |
| 样本类型 |
血清，血浆，细胞培养上清及其他生物学样本 |
| 板式 |
管 |
| 保存 |
短期4℃，长期-20℃保存 |
| 运输条件 |
4℃蓝冰运输 |
检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠TSLP抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的TSLP与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中TSLP的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。
分子信息
TSLP 分子靶点信息概述
- 分子名：TSLP, thymic stromal lymphopoietin
TSLP 分子靶点综述
胸腺基质淋巴细胞生成素(TSLP)主要由非造血细胞如成纤维细胞、上皮细胞和不同类型的基质或基质样细胞产生。它主要影响骨髓细胞、诱导单核细胞释放T细胞虏获趋化因子和增强髓样(CD11c+)树突状细胞成熟。研究表明，TSLP还可激活位于表皮的特定树突状细胞亚群—朗格汉斯细胞的成熟。胸腺TSLP激活髓样和浆细胞样(CD123+)树突状细胞会导致调节性T细胞的产生。TSLP通过胸腺基质淋巴细胞受体CRLF2和IL-7Rα链组成的异源二聚体受体复合物产生信号。结合STAT5后就会诱导其发生磷酸化，进而导致上游转录因子的表达。TSLP的表达与许多疾病包括哮喘、炎症性关节炎、特应性皮炎、湿疹及其它过敏状态有关。
小鼠 Mouse Tslp 分子靶点信息
- 分子名：Tslp, thymic stromal lymphopoietin
- 别称：
- 无
- 基因序列：NCBI_Gene: 53603
- 蛋白序列：
小鼠 Mouse Tslp 靶点分子功能（预测）
Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in ductus deferens; epididymis; ileum; and testis. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin).
引用文献
文章目录[隐藏]
- Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders
- Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis
- Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo
- The Involvement of Type 2 Innate Lymphoid Cells in Airway Inflammation of Asthma
- IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation
- Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways
- Celastrol alleviates atopic dermatitis by regulating Ezrin-mediated mitochondrial fission and fusion
- Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1/2 balance
- Effects of total alkaloids from Alstonia scholaris (L.) R. Br. on ovalbumin-induced asthma mice
- CKBA suppresses mast cell activation via ERK signaling pathway in murine atopic dermatitis
- Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived Cytokines
- Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis
Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders
Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis
Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo
The Involvement of Type 2 Innate Lymphoid Cells in Airway Inflammation of Asthma
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation
Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways
Celastrol alleviates atopic dermatitis by regulating Ezrin-mediated mitochondrial fission and fusion
Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1/2 balance
Effects of total alkaloids from Alstonia scholaris (L.) R. Br. on ovalbumin-induced asthma mice
CKBA suppresses mast cell activation via ERK signaling pathway in murine atopic dermatitis
Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived Cytokines
- 支气管肺泡灌洗液 BALF
Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis
相关产品
-
- EK101AS
- ELISA标准品
Human IL-1α Standard (人白介素1α 标准品)
- ¥180.00
-
- EK109S
- ELISA标准品
Human IL-9 Standard (人白细胞介素9标准品)
- ¥280.00
-
- EK1101S
- ELISA标准品
Human sCD14 Standard (人可溶性CD14 标准品)
- ¥280.00
-
- EK165
- ELISA试剂盒
Human TSLP ELISA Kit检测试剂盒（酶联免疫吸附法）
- ¥1,600.00 – ¥2,650.00
-
- EK165S
- ELISA标准品
Human TSLP Standard (人胸腺基质淋巴细胞生成素 标准品)
- ¥180.00
-
- EK265
- ELISA试剂盒
Mouse TSLP ELISA Kit检测试剂盒（酶联免疫吸附法）
- ¥1,600.00 – ¥2,650.00
-
- EK102S
- ELISA标准品
Human IL-2 Standard (人白介素2 标准品)
- ¥580.00
评价
目前还没有评价