Mouse TRANCE/TNFSF11/RANKL Standard (小鼠肿瘤坏死因子相关激活诱导因子/肿瘤坏死因子配体超家族成员11/核因子κB受体活化因子配基 标准品)

TNFSF11 分子靶点信息概述

• 分子名：TNFSF11, TNF superfamily member 11
• 基因家族：CD molecules; Tumor necrosis factor superfamily
• 别名：TRANCE; RANKL; OPGL; ODF; CD254
• 全称：tumor necrosis factor (ligand) superfamily, member 11

TNFSF11 分子靶点综述

肿瘤坏死因子相关激活诱导因子(TRANCE)，又名肿瘤坏死因子配体超家族成员11(TNFSF11)、核因子κB受体活化因子配基(RANKL)，是TNF超家族成员。成骨细胞、CD4+和CD8+T细胞、巨核细胞、支气管和肠道上皮细胞等都可表达TRANCE。TRANCE在免疫应答和骨形态发生中起核心作用。在骨形成和重塑过程中，成骨细胞表达的TRANCE与M-CSF一起诱导破骨细胞形成和活化，导致骨吸收，进而导致随后的骨沉积和重塑。TRANCE同样在病理性骨质疏松中起作用。活化的淋巴细胞和成骨细胞不恰当表达TRANCE就会导致关节和骨头的过度吸收与沉积。过量的TRANCE与许多退行性骨疾病，如类风湿性关节炎、银屑病性关节炎有关。

小鼠 Mouse Tnfsf11 分子靶点信息

• 分子名：Tnfsf11, tumor necrosis factor (ligand) superfamily, member 11
• 别称：
  • Ly109l
  • ODF
  • OPGL
  • osteoclast differentiation factor
  • RANKL
  • TNF-related activation-induced cytokine
  • Trance
• 基因序列：NCBI_Gene: 21943
• 蛋白序列：
  • UniprotKB: O35235
  • UniprotKB: Q059M3

小鼠 Mouse Tnfsf11 靶点分子功能（预测）

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).