TNFSF11 靶点信息

TNFSF11 分子靶点信息概述

  • 分子名：TNFSF11, TNF superfamily member 11
  • 基因家族：CD molecules; Tumor necrosis factor superfamily
  • 别名：TRANCE; RANKL; OPGL; ODF; CD254
  • 全称：tumor necrosis factor (ligand) superfamily, member 11

TNFSF11 分子靶点综述

肿瘤坏死因子相关激活诱导因子(TRANCE)，又名肿瘤坏死因子配体超家族成员11(TNFSF11)、核因子κB受体活化因子配基(RANKL)，是TNF超家族成员。成骨细胞、CD4+和CD8+T细胞、巨核细胞、支气管和肠道上皮细胞等都可表达TRANCE。TRANCE在免疫应答和骨形态发生中起核心作用。在骨形成和重塑过程中，成骨细胞表达的TRANCE与M-CSF一起诱导破骨细胞形成和活化，导致骨吸收，进而导致随后的骨沉积和重塑。TRANCE同样在病理性骨质疏松中起作用。活化的淋巴细胞和成骨细胞不恰当表达TRANCE就会导致关节和骨头的过度吸收与沉积。过量的TRANCE与许多退行性骨疾病，如类风湿性关节炎、银屑病性关节炎有关。

TNFSF11, TNF superfamily member 11 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFSF11 分子靶点信息

  • 分子名：TNFSF11, TNF superfamily member 11
  • 别称：
    • CD254
    • hRANKL2
    • ODF
    • OPGL
    • OPTB2
    • osteoclast differentiation factor
    • osteoprotegerin ligand
    • RANKL
    • receptor activator of nuclear factor kappa B ligand
    • receptor activator of nuclear factor kappa-B ligand
    • sOdf
    • TNF-related activation-induced cytokine
    • TNLG6B
    • TRANCE
    • tumor necrosis factor (ligand) superfamily member 11
    • tumor necrosis factor (ligand) superfamily, member 11
    • tumor necrosis factor ligand 6B
    • tumor necrosis factor ligand superfamily member 11
    • tumor necrosis factor superfamily member 11
  • 基因序列：NCBI_Gene: 8600
  • 蛋白序列：UniProtKB: O14788

人 Human TNFSF11靶点分子功能（预测）

Enables cytokine activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of cell-cell adhesion; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region and plasma membrane. Implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Biomarker of myocardial infarction.

小鼠 Mouse Tnfsf11 分子靶点信息

  • 分子名：Tnfsf11, tumor necrosis factor (ligand) superfamily, member 11
  • 别称：
    • Ly109l
    • ODF
    • OPGL
    • osteoclast differentiation factor
    • RANKL
    • TNF-related activation-induced cytokine
    • Trance
  • 基因序列：NCBI_Gene: 21943
  • 蛋白序列：

小鼠 Mouse Tnfsf11 靶点分子功能（预测）

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of secretion by cell; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including animal organ development; cellular response to cytokine stimulus; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm; extracellular space; and plasma membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; hemolymphoid system; hindlimb long bone; and lymphatic system. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).

大鼠 Rat Tnfsf11 分子靶点信息

  • 分子名：Tnfsf11, TNF superfamily member 11
  • 别称：
    • LOC103689974
    • ODF
    • OPGL
    • osteoclast differentiation factor
    • osteoprotegerin ligand
    • RANKL
    • receptor activator of nuclear factor kappa B ligand
    • receptor activator of nuclear factor kappa-B ligand
    • TNF-related activation-induced cytokine
    • TRANCE
    • tumor necrosis factor (ligand) superfamily, member 11
    • tumor necrosis factor ligand superfamily member 11
    • tumor necrosis factor superfamily member 11
  • 基因序列：NCBI_Gene: 117516
  • 蛋白序列：

大鼠 Rat Tnfsf11 靶点分子功能（预测）

Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Biomarker of mucopolysaccharidosis VI and myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11).

TNFSF11 分子产品列表

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