Mouse RAGE Standard (小鼠晚期糖基化终末产物受体 (RAGE) 标准品)

AGER 分子靶点信息概述

• 分子名：AGER, advanced glycosylation end-product specific receptor
• 基因家族：C2-set domain containing; Scavenger receptors
• 别名：RAGE; SCARJ1; sRAGE
• 全称：receptor for advanced glycation end-products

AGER 分子靶点综述

晚期糖基化终末产物受体 (RAGE)是35 kDa的免疫球超家族跨膜受体，其名字来自于与晚期糖基化终末产物结合的能力。鉴于其在先天免疫的炎症功能和通过共同基序识别一类配体的能力，RAGE通常被认为是一类识别受体。RAGE与一些慢性疾病有关，如动脉粥样硬化、末梢血管疾病、心肌梗死、充血性心力衰竭、糖尿病、阿尔茨海默病等。与其它组织相比，RAGE在肺部表达量最高，尤其是在I型肺泡上皮细胞，而在特发性肺纤维化 (IPF)中不表达，这表明RAGE在肺系中的表达和调控与心血管系统中不同。阻断/敲除RAGE会导致细胞黏附受损，增加细胞增殖和迁移。

小鼠 Mouse Ager 分子靶点信息

• 分子名：Ager, advanced glycosylation end product-specific receptor
• 别称：
  • RAGE
• 基因序列：NCBI_Gene: 11596
• 蛋白序列：
  • UniprotKB: Q62151
  • UniprotKB: F1ABR7
  • UniprotKB: F1ABR8
  • UniprotKB: F1ABR9
  • UniprotKB: F1ABS0
  • UniprotKB: F1ABS1
  • UniprotKB: F1ABS2

小鼠 Mouse Ager 靶点分子功能（预测）

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).