AGER 靶点信息

AGER 分子靶点信息概述

  • 分子名：AGER, advanced glycosylation end-product specific receptor
  • 基因家族：C2-set domain containing; Scavenger receptors
  • 别名：RAGE; SCARJ1; sRAGE
  • 全称：receptor for advanced glycation end-products

AGER 分子靶点综述

晚期糖基化终末产物受体 (RAGE)是35 kDa的免疫球超家族跨膜受体，其名字来自于与晚期糖基化终末产物结合的能力。鉴于其在先天免疫的炎症功能和通过共同基序识别一类配体的能力，RAGE通常被认为是一类识别受体。RAGE与一些慢性疾病有关，如动脉粥样硬化、末梢血管疾病、心肌梗死、充血性心力衰竭、糖尿病、阿尔茨海默病等。与其它组织相比，RAGE在肺部表达量最高，尤其是在I型肺泡上皮细胞，而在特发性肺纤维化 (IPF)中不表达，这表明RAGE在肺系中的表达和调控与心血管系统中不同。阻断/敲除RAGE会导致细胞黏附受损，增加细胞增殖和迁移。

AGER, advanced glycosylation end-product specific receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human AGER 分子靶点信息

  • 分子名：AGER, advanced glycosylation end-product specific receptor
  • 别称：
    • advanced glycosylation end product-specific receptor
    • MGC22357
    • RAGE
    • RAGE isoform delta
    • RAGE isoform NtRAGE-delta
    • RAGE isoform sRAGE-delta
    • receptor for advanced glycation end-products variant 20
    • receptor for advanced glycosylation end products
    • receptor for advanced glycosylation end-products
    • SCARJ1
    • sRAGE
  • 基因序列：NCBI_Gene: 177
  • 蛋白序列：UniProtKB: Q15109

人 Human AGER靶点分子功能（预测）

Enables several functions, including S100 protein binding activity; amyloid-beta binding activity; and identical protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in apical plasma membrane; cell junction; and fibrillar center. Implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease (multiple); congestive heart failure (multiple); diabetic retinopathy (multiple); and lung disease (multiple).

小鼠 Mouse Ager 分子靶点信息

小鼠 Mouse Ager 靶点分子功能（预测）

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

大鼠 Rat Ager 分子靶点信息

大鼠 Rat Ager 靶点分子功能（预测）

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

AGER 分子产品列表

AGER 分子靶点最新资讯