Mouse IL-6Rα Standard (小鼠白介素6受体α 标准品)

IL6R 分子靶点信息概述

• 分子名：IL6R, interleukin 6 receptor
• 基因家族：CD molecules; Immunoglobulin like domain containing; Interleukin receptors
• 别名：CD126; IL-6R; IL-1Ra; IL6RA; gp80
• 全称：membrane glycoprotein 80; interleukin 6 receptor subunit alpha

IL6R 分子靶点综述

白细胞介素 6 受体是由 IL-6 受体亚基(IL-6Rα)和信号转导糖蛋白 130(gp130)组成的复合物。可溶性IL-6Rα的分子量约 50kDa，由膜 IL-6Rα经蛋白水解产生。该受体可在溶液中与 IL-6 结合，使 IL-6/IL-6sRα复合物与膜gp130 结合，增强IL-6 活性。目前调控体内可溶性 IL-6R 的脱落以及这些受体的功能和重要性尚未知。然而涉及 IL-6 水平升高的病理状态也许与可溶性 IL-6R 含量升高有关。

小鼠 Mouse Il6ra 分子靶点信息

• 分子名：Il6ra, interleukin 6 receptor, alpha
• 别称：
  • CD126
  • IL-6 receptor alpha chain
  • IL-6R
  • Il6r
  • interleukin 6 receptor
• 基因序列：NCBI_Gene: 16194
• 蛋白序列：
  • UniprotKB: P22272
  • UniprotKB: A0A0G2JGF1
  • UniprotKB: Q3URV7
  • UniprotKB: V9H161

小鼠 Mouse Il6ra 靶点分子功能（预测）

Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).