IL6R 靶点信息

IL6R 分子靶点信息概述

  • 分子名：IL6R, interleukin 6 receptor
  • 基因家族：CD molecules; Immunoglobulin like domain containing; Interleukin receptors
  • 别名：CD126; IL-6R; IL-1Ra; IL6RA; gp80
  • 全称：membrane glycoprotein 80; interleukin 6 receptor subunit alpha

IL6R 分子靶点综述

白细胞介素1受体拮抗剂(IL-1ra)是白细胞介素1(IL-1)细胞因子家族中的一员，由多种细胞包括免疫细胞、上皮细胞和脂肪细胞分泌产生，是IL-1β促炎症作用的天然抑制剂。IL-ra是一种介质，可非高效结合细胞表面的白细胞介素1受体(IL-1R)。而IL-1R也是结合IL-1的受体，因此IL-1ra可阻止IL-1向细胞发送信号。该蛋白抑制IL-1α和IL-1β活性，调节多种IL-1相关的免疫和炎症反应。IL-1RN基因多态性与骨质疏松性骨折和胃癌风险的增加有关。该基因突变将导致一种罕见疾病即IL-1ra缺陷的发生。该基因突变也与精神分裂症发生的风险有关。它被用于治疗类风湿性关节炎。

IL6R, interleukin 6 receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL6R 分子靶点信息

  • 分子名：IL6R, interleukin 6 receptor
  • 别称：
    • CD126
    • CD126 antigen
    • gp80
    • HIES5
    • IL-1Ra
    • IL-6 receptor subunit alpha
    • IL-6R
    • IL-6R 1
    • IL-6R subunit alpha
    • IL-6R-1
    • IL-6R-alpha
    • IL-6RA
    • IL6Q
    • IL6QTL
    • IL6RA
    • IL6RQ
    • interleukin 6 receptor alpha subunit
    • interleukin-6 receptor subunit alpha
    • membrane glycoprotein 80
    • MGC104991
  • 基因序列：NCBI_Gene: 3570
  • 蛋白序列：UniProtKB: P08887

人 Human IL6R靶点分子功能（预测）

Enables cytokine binding activity; enzyme binding activity; and protein homodimerization activity. Contributes to ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; and interleukin-6 receptor binding activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Located in apical plasma membrane and extracellular space. Part of ciliary neurotrophic factor receptor complex and interleukin-6 receptor complex. Implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Biomarker of several diseases, including Graves' disease; obesity; proliferative diabetic retinopathy; pulmonary tuberculosis; and sleep apnea.

小鼠 Mouse Il6ra 分子靶点信息

小鼠 Mouse Il6ra 靶点分子功能（预测）

Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).

大鼠 Rat Il6r 分子靶点信息

  • 分子名：Il6r, interleukin 6 receptor
  • 别称：
    • IL-6 receptor subunit alpha
    • IL-6R 1
    • IL-6R subunit alpha
    • IL-6R-alpha
    • IL-6RA
    • IL6R1
    • Il6ra
    • interleukin 6 receptor, alpha
    • interleukin-6 receptor subunit alpha
  • 基因序列：NCBI_Gene: 24499
  • 蛋白序列：

大鼠 Rat Il6r 靶点分子功能（预测）

Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).

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