Mouse GM-CSF Standard (小鼠粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 标准品)

CSF2 分子靶点信息概述

• 分子名：CSF2, colony stimulating factor 2
• 别名：GM-CSF; GMCSF
• 全称：sargramostim; molgramostim; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage)

CSF2 分子靶点综述

粒细胞-巨噬细胞集落刺激因子(GM-CSF)是一种调节白细胞生长的细胞因子。GM-CSF刺激干细胞产生粒细胞(中性粒细胞、嗜酸性粒细胞和嗜碱性粒细胞)及单核细胞。此外，它对造血和非造血谱系细胞也具有活性。GM-CSF用作药物来刺激白细胞的产生，从而预防化疗后引起的中性粒细胞减少症。近来，人们正在临床试验评估GM-CSF作为一种潜在的疫苗佐剂对HIV感染患者的疗效。相关研究报道一些癌症(包括肺癌和急性髓细胞白血病)患者的血清中具有较高水平的GM-CSF，同样在支气管哮喘患者外周血和鳞屑提取物中也具有较高水平的GM-CSF。

小鼠 Mouse Csf2 分子靶点信息

• 分子名：Csf2, colony stimulating factor 2 (granulocyte-macrophage)
• 别称：
  • colony stimulating factor, granulocyte macrophage
  • Csfgm
  • Gm-CSf
  • GMCSF
  • MGI-IGM
• 基因序列：NCBI_Gene: 12981
• 蛋白序列：
  • UniprotKB: P01587
  • UniprotKB: Q14AD9
  • UniprotKB: Q5SX78

小鼠 Mouse Csf2 靶点分子功能（预测）

Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; labyrinthine zone; liver; and lung. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2).