Mouse FGF acidic Standard (小鼠FGF acidic 标准品)

FGF1 分子靶点信息概述

• 分子名：FGF1, fibroblast growth factor 1
• 基因家族：Receptor ligands; Fibroblast growth factor family
• 别名：AFGF; ECGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703
• 曾用名：FGFA
• 全称：heparin-binding growth factor 1; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; fibroblast growth factor 1 (acidic)

FGF1 分子靶点综述

酸性成纤维细胞生长因子(FGF acidic)，也称为FGF-1、ECGF和HBGF-1，它是一种分泌型有丝分裂原，可以刺激中胚层来源的所有细胞和神经外胚层、外胚层和内胚层来源的细胞的增殖。它在发育、再生和血管生成中均发挥作用。内化的FGF acidic可以在Hsp90的帮助下转移至细胞质中，然后通过其两个核定位信号迁移到细胞核。PKCδ磷酸化的FGF acidic可触发主动输出至胞质中，在这里去磷酸化和降解。在细胞内，FGF acidic通过抑制p53活性和促凋亡传导信号而起到存活因子的作用。

小鼠 Mouse Fgf1 分子靶点信息

• 分子名：Fgf1, fibroblast growth factor 1
• 别称：
  • Fgf-1
  • Fgfa
  • fibroblast growth factor 1 (acidic)
  • fibroblast growth factor, acidic
• 基因序列：NCBI_Gene: 14164
• 蛋白序列：
  • UniprotKB: P61148
  • UniprotKB: A0A494BBG9
  • UniprotKB: D3Z192
  • UniprotKB: D3Z6E2
  • UniprotKB: D3Z6H1
  • UniprotKB: D6RCX9
  • UniprotKB: O54837
  • UniprotKB: Q6ZWS1

小鼠 Mouse Fgf1 靶点分子功能（预测）

Predicted to enable several functions, including Hsp70 protein binding activity; S100 protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including organ induction; positive regulation of epithelial cell proliferation; and positive regulation of nitrogen compound metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).