FGF1 靶点信息

FGF1 分子靶点信息概述

  • 分子名：FGF1, fibroblast growth factor 1
  • 基因家族：Receptor ligands; Fibroblast growth factor family
  • 别名：AFGF; ECGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703
  • 曾用名：FGFA
  • 全称：heparin-binding growth factor 1; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; fibroblast growth factor 1 (acidic)

FGF1 分子靶点综述

酸性成纤维细胞生长因子(FGF acidic)，也称为FGF-1、ECGF和HBGF-1，它是一种分泌型有丝分裂原，可以刺激中胚层来源的所有细胞和神经外胚层、外胚层和内胚层来源的细胞的增殖。它在发育、再生和血管生成中均发挥作用。内化的FGF acidic可以在Hsp90的帮助下转移至细胞质中，然后通过其两个核定位信号迁移到细胞核。PKCδ磷酸化的FGF acidic可触发主动输出至胞质中，在这里去磷酸化和降解。在细胞内，FGF acidic通过抑制p53活性和促凋亡传导信号而起到存活因子的作用。

FGF1, fibroblast growth factor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGF1 分子靶点信息

  • 分子名：FGF1, fibroblast growth factor 1
  • 别称：
    • acidic fibroblast growth factor
    • AFGF
    • beta-endothelial cell growth factor
    • ECGF
    • ECGF-beta
    • ECGFA
    • ECGFB
    • endothelial cell growth factor
    • endothelial cell growth factor, alpha
    • endothelial cell growth factor, beta
    • FGF-1
    • FGF-alpha
    • FGFA
    • fibroblast growth factor 1 (acidic)
    • GLIO703
    • HBGF-1
    • HBGF1
    • heparin-binding growth factor 1
  • 基因序列：NCBI_Gene: 2246
  • 蛋白序列：UniProtKB: P05230

人 Human FGF1靶点分子功能（预测）

Enables S100 protein binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of biosynthetic process; and regulation of endothelial cell migration. Located in cytosol; extracellular space; and nucleoplasm. Implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Biomarker of Alzheimer's disease; endometrial cancer; leiomyoma; ovarian cancer; and transitional cell carcinoma.

小鼠 Mouse Fgf1 分子靶点信息

小鼠 Mouse Fgf1 靶点分子功能（预测）

Predicted to enable several functions, including Hsp70 protein binding activity; S100 protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including organ induction; positive regulation of epithelial cell proliferation; and positive regulation of nitrogen compound metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).

大鼠 Rat Fgf1 分子靶点信息

  • 分子名：Fgf1, fibroblast growth factor 1
  • 别称：
    • acidic fibroblast growth factor
    • aFGF
    • FGF-1
    • Fgf2b
    • fibroblast growth factor 1 (acidic)
    • Fibroblast growth factor 1 (heparin binding)
    • fibroblast growth factor 2b
    • HBGF-1
    • HBGF1
    • heparin-binding growth factor 1
  • 基因序列：NCBI_Gene: 25317
  • 蛋白序列：

大鼠 Rat Fgf1 靶点分子功能（预测）

Enables Hsp70 protein binding activity and growth factor activity. Involved in positive regulation of hepatocyte proliferation. Located in cytoplasm and nucleolus. Used to study brain ischemia. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1).

FGF1 分子产品列表

FGF1 分子靶点最新资讯

论文分享 | Cell子刊：膳食纤维通过肠道菌群减轻酒精性肝病 

（7月文献汇总）Cell旗下子刊Cell Host & Microbe引用联科产品