Mouse E-Cadherin Standard (小鼠E-钙粘蛋白 (E-Cadherin) 标准品)

CDH1 分子靶点信息概述

• 分子名：CDH1, cadherin 1
• 基因家族：CD molecules; Type I classical cadherins
• 别名：uvomorulin; CD324
• 曾用名：UVO
• 全称：E-Cadherin; cadherin 1, type 1, E-cadherin (epithelial)

CDH1 分子靶点综述

CDH1，又名上皮细胞钙粘素和CD324，是一种钙依赖性的细胞粘附分子。它包括胞外结构域的5个重复钙粘蛋白、一个跨膜结构域和一个可结合p120-联蛋白和β-联蛋白的胞内结构域。成人组织的CDH1在上皮组织中表达，在那里它可不断地再生，它在细胞表面的半衰期是5个小时。CDH1功能或表达缺失与肿瘤的进展和转移有关，下调CDH1的表达可降低细胞在组织中的粘附强度，导致细胞运动增加。反过来，它可允许癌细胞穿过基底膜，浸入周围组织。病理学家通常用CDH1来诊断不同类型的乳腺癌。免疫组化研究表明，与浸润性导管癌相比，浸润性小叶癌的CDH1表达显著降低或绝大多数缺失。

小鼠 Mouse Cdh1 分子靶点信息

• 分子名：Cdh1, cadherin 1
• 别称：
  • AA960649
  • E-cad
  • E-cadherin
  • Ecad
  • expressed sequence AA960649
  • L-CAM
  • Um
  • UM
  • uvomorulin
• 基因序列：NCBI_Gene: 12550
• 蛋白序列：
  • UniprotKB: P09803
  • UniprotKB: A0A0R4IZW5
  • UniprotKB: Q4KML8

小鼠 Mouse Cdh1 靶点分子功能（预测）

Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in several processes, including cochlea development; embryo implantation; and reproductive structure development. Acts upstream of or within several processes, including bicellular tight junction assembly; epithelial cell development; and regulation of proteolysis. Located in several cellular components, including Schmidt-Lanterman incisure; axon; and basolateral plasma membrane. Part of catenin complex and flotillin complex. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).