CDH1 靶点信息

CDH1 分子靶点信息概述

  • 分子名：CDH1, cadherin 1
  • 基因家族：CD molecules; Type I classical cadherins
  • 别名：uvomorulin; CD324
  • 曾用名：UVO
  • 全称：E-Cadherin; cadherin 1, type 1, E-cadherin (epithelial)

CDH1 分子靶点综述

CDH1，又名上皮细胞钙粘素和CD324，是一种钙依赖性的细胞粘附分子。它包括胞外结构域的5个重复钙粘蛋白、一个跨膜结构域和一个可结合p120-联蛋白和β-联蛋白的胞内结构域。成人组织的CDH1在上皮组织中表达，在那里它可不断地再生，它在细胞表面的半衰期是5个小时。CDH1功能或表达缺失与肿瘤的进展和转移有关，下调CDH1的表达可降低细胞在组织中的粘附强度，导致细胞运动增加。反过来，它可允许癌细胞穿过基底膜，浸入周围组织。病理学家通常用CDH1来诊断不同类型的乳腺癌。免疫组化研究表明，与浸润性导管癌相比，浸润性小叶癌的CDH1表达显著降低或绝大多数缺失。

CDH1, cadherin 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CDH1 分子靶点信息

  • 分子名：CDH1, cadherin 1
  • 别称：
    • Arc-1
    • BCDS1
    • cadherin 1, E-cadherin (epithelial)
    • cadherin 1, type 1
    • cadherin 1, type 1, E-cadherin (epithelial)
    • cadherin-1
    • calcium-dependent adhesion protein, epithelial
    • CAM 120/80
    • CD324
    • CDHE
    • cell-CAM 120/80
    • E-Cadherin
    • E-cadherin 1
    • ECAD
    • epithelial cadherin
    • LCAM
    • UVO
    • uvomorulin
  • 基因序列：NCBI_Gene: 999
  • 蛋白序列：UniProtKB: P12830

人 Human CDH1靶点分子功能（预测）

Enables several functions, including GTPase activating protein binding activity; ankyrin binding activity; and beta-catenin binding activity. Involved in several processes, including cellular response to indole-3-methanol; cellular response to lithium ion; and positive regulation of protein import into nucleus. Located in several cellular components, including adherens junction; lateral plasma membrane; and trans-Golgi network. Is integral component of membrane. Part of catenin complex and flotillin complex. Colocalizes with cortical actin cytoskeleton. Implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including endocrine gland cancer (multiple); invasive lobular carcinoma; oral squamous cell carcinoma; prostate cancer; and pulmonary fibrosis.

小鼠 Mouse Cdh1 分子靶点信息

小鼠 Mouse Cdh1 靶点分子功能（预测）

Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in several processes, including cochlea development; embryo implantation; and reproductive structure development. Acts upstream of or within several processes, including bicellular tight junction assembly; epithelial cell development; and regulation of proteolysis. Located in several cellular components, including Schmidt-Lanterman incisure; axon; and basolateral plasma membrane. Part of catenin complex and flotillin complex. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).

大鼠 Rat Cdh1 分子靶点信息

大鼠 Rat Cdh1 靶点分子功能（预测）

Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1).

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