Mouse C-Reactive Protein/CRP Standard (小鼠C-反应蛋白 标准品)

CRP 分子靶点信息概述

• 分子名：CRP, C-reactive protein
• 基因家族：Short pentraxins
• 别名：PTX1
• 全称：pentraxin 1; C-reactive protein, pentraxin-related

CRP 分子靶点综述

C-反应蛋白(CRP)是在血浆中发现的一种环状、五聚体蛋白。肝脏对巨噬细胞和脂肪细胞释放的因子产生应答后可合成CRP。CRP是一种肝源性的急性蛋白，在巨噬细胞和T细胞分泌白介素6后增加，其生理作用是与死细胞或濒死细胞(和某些类型的细菌)表面的溶血磷脂胆碱结合，以通过C1Q复合物来激活补体系统。它与C-肽(胰岛素)或蛋白C(血凝)不相关。CRP通常作为炎症标志物，当机体受到炎症感染时，CRP水平会上升。最近的研究表明，患者具有较高基础水平的CRP，通常伴随着一个较高糖尿病、高血压和心血管疾病的发生率。

小鼠 Mouse Crp 分子靶点信息

• 分子名：Crp, C-reactive protein, pentraxin-related
• 别称：
  • AI255847
  • expressed sequence AI255847
• 基因序列：NCBI_Gene: 12944
• 蛋白序列：
  • UniprotKB: P14847
  • UniprotKB: I6L966
  • UniprotKB: Q542I3

小鼠 Mouse Crp 靶点分子功能（预测）

Predicted to enable several functions, including cholesterol binding activity; complement component C1q complex binding activity; and low-density lipoprotein particle binding activity. Predicted to be involved in several processes, including complement activation, classical pathway; regulation of gene expression; and regulation of superoxide anion generation. Predicted to act upstream of or within vasoconstriction. Predicted to be located in filopodium and growth cone. Predicted to be active in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein).