Human VEGF R3/Flt-4 Standard (人血管内皮生长因子受体3 (VEGF R3) 标准品)

FLT4 分子靶点信息概述

• 分子名：FLT4, fms related receptor tyrosine kinase 4
• 基因家族：Receptor tyrosine kinases; I-set domain containing
• 别名：VEGFR3; PCL; VEGFR-3
• 全称：vascular endothelial growth factor receptor 3; VEGF receptor-3; Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4; primary congenital lymphedema; fms-related tyrosine kinase 4; fms related tyrosine kinase 4

FLT4 分子靶点综述

血管内皮生长因子受体3 (VEGF R3)，又名Flt-4，是VEGF-C和VEGF-D的酪氨酸激酶受体。该蛋白参与淋巴管内皮中的淋巴管生成和维护。人们可从淋巴瘤患者癌组织中分离的淋巴内皮细胞里发现高表达的VEGF R3。VEGF R3基因突变导致IA型遗传性淋巴水肿。一些研究表明VEGF-C、VEGF-D、VEGF R3的表达与血管侵犯、淋巴管和淋巴结的参与之间呈正相关关系。VEGF-C/VEGF-D/VEGFR3信号通路可为前列腺癌、乳腺癌、胃癌、肺癌、非小细胞肺癌等的抗淋巴管生成治疗提供靶点。

人 Human FLT4 分子靶点信息

• 分子名：FLT4, fms related receptor tyrosine kinase 4
• 别称：
  • CHTD7
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • FLT-4
  • FLT41
  • fms related tyrosine kinase 4
  • fms-like tyrosine kinase 4
  • fms-related tyrosine kinase 4
  • LMPH1A
  • LMPHM1
  • PCL
  • primary congenital lymphedema
  • soluble VEGFR3 variant 1
  • soluble VEGFR3 variant 2
  • soluble VEGFR3 variant 3
  • tyrosine-protein kinase receptor FLT4
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • VEGFR-3
  • VEGFR3
• 基因序列：NCBI_Gene: 2324
• 蛋白序列：UniProtKB: P35916

人 Human FLT4靶点分子功能（预测）

Enables several functions, including protein homodimerization activity; protein phosphatase binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and protein phosphorylation. Acts upstream of or within vascular endothelial growth factor receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. Implicated in hereditary lymphedema IA. Biomarker of lymphangioma and systemic scleroderma.