FLT4 靶点信息

FLT4 分子靶点信息概述

  • 分子名：FLT4, fms related receptor tyrosine kinase 4
  • 基因家族：Receptor tyrosine kinases; I-set domain containing
  • 别名：VEGFR3; PCL; VEGFR-3
  • 全称：vascular endothelial growth factor receptor 3; VEGF receptor-3; Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4; primary congenital lymphedema; fms-related tyrosine kinase 4; fms related tyrosine kinase 4

FLT4 分子靶点综述

血管内皮生长因子受体3 (VEGF R3)，又名Flt-4，是VEGF-C和VEGF-D的酪氨酸激酶受体。该蛋白参与淋巴管内皮中的淋巴管生成和维护。人们可从淋巴瘤患者癌组织中分离的淋巴内皮细胞里发现高表达的VEGF R3。VEGF R3基因突变导致IA型遗传性淋巴水肿。一些研究表明VEGF-C、VEGF-D、VEGF R3的表达与血管侵犯、淋巴管和淋巴结的参与之间呈正相关关系。VEGF-C/VEGF-D/VEGFR3信号通路可为前列腺癌、乳腺癌、胃癌、肺癌、非小细胞肺癌等的抗淋巴管生成治疗提供靶点。

FLT4, fms related receptor tyrosine kinase 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FLT4 分子靶点信息

  • 分子名：FLT4, fms related receptor tyrosine kinase 4
  • 别称：
    • CHTD7
    • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
    • FLT-4
    • FLT41
    • fms related tyrosine kinase 4
    • fms-like tyrosine kinase 4
    • fms-related tyrosine kinase 4
    • LMPH1A
    • LMPHM1
    • PCL
    • primary congenital lymphedema
    • soluble VEGFR3 variant 1
    • soluble VEGFR3 variant 2
    • soluble VEGFR3 variant 3
    • tyrosine-protein kinase receptor FLT4
    • vascular endothelial growth factor receptor 3
    • VEGF receptor-3
    • VEGFR-3
    • VEGFR3
  • 基因序列：NCBI_Gene: 2324
  • 蛋白序列：UniProtKB: P35916

人 Human FLT4靶点分子功能（预测）

Enables several functions, including protein homodimerization activity; protein phosphatase binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and protein phosphorylation. Acts upstream of or within vascular endothelial growth factor receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. Implicated in hereditary lymphedema IA. Biomarker of lymphangioma and systemic scleroderma.

小鼠 Mouse Flt4 分子靶点信息

小鼠 Mouse Flt4 靶点分子功能（预测）

Enables vascular endothelial growth factor-activated receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and extraembryonic component. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).

大鼠 Rat Flt4 分子靶点信息

  • 分子名：Flt4, Fms related receptor tyrosine kinase 4
  • 别称：
    • FLT-4
    • FMS-like tyrosine kinase 4
    • fms-related tyrosine kinase 4
    • LOC360235
    • tyrosine-protein kinase receptor FLT4
    • vascular endothelial growth factor receptor 3
    • VEGFR-3
    • Vegfr3
  • 基因序列：NCBI_Gene: 114110
  • 蛋白序列：

大鼠 Rat Flt4 靶点分子功能（预测）

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).

FLT4 分子产品列表

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