EK1109S

Human sTNF RI/TNFRSF1A Standard (人可溶性肿瘤坏死因子受体1 标准品)

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¥180.00

  • 分子靶点:TNFRSF1A, TNFR1, CD120a
  • 种属:人 (Human)
  • 试剂盒:EK1109
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1109S, 可溶性, 肿瘤, 坏死, 因子, 受体, 1


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human sTNF RI/TNFRSF1A Standard (人可溶性肿瘤坏死因子受体1Standard)

组分

人可溶性肿瘤坏死因子受体1标准品

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人sTNF RI抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的sTNF RI与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中sTNF RI的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human sTNF RI/TNFRSF1A ELISA Kit (人可溶性肿瘤坏死因子受体1ELISA Kit) - 标准曲线
标准曲线

分子信息

概述人 TNFRSF1A, TNFR1, CD120a 靶点信息

TNFRSF1A 分子靶点信息概述

  • 分子名:TNFRSF1A, TNF receptor superfamily member 1A
  • 基因家族:CD molecules; Tumor necrosis factor receptor superfamily
  • 别名:TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
  • 曾用名:TNFR1
  • 全称:tumor necrosis factor receptor superfamily, member 1A

TNFRSF1A 分子靶点综述

肿瘤坏死因子受体1(TNFRI),又名肿瘤坏死因子受体超家族成员1A(TNFRSF1A)和CD120a,是肿瘤坏死因子受体超家族的一员。它能激活转录因子NF-κB、介导细胞凋亡和调控炎症。TNFRI基因突变与多发性硬化症风险增加有关。精神分裂症和双相情感障碍患者血清中的TNFRI水平是升高的,且高水平的TNFRI与更严重的精神病症状有关。

人 Human TNFRSF1A 分子靶点信息

  • 分子名:TNFRSF1A, TNF receptor superfamily member 1A
  • 别称:
    • CD120a
    • FPF
    • MGC19588
    • MS5
    • p55
    • p55-R
    • p60
    • TBP1
    • TNF-R
    • TNF-R-I
    • TNF-R1
    • TNF-R55
    • TNF-RI
    • TNFAR
    • TNFR-I
    • TNFR1
    • TNFR1-d2
    • TNFR55
    • TNFR60
    • tumor necrosis factor binding protein 1
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 1A isoform beta
    • tumor necrosis factor receptor superfamily member 1A
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor type 1
    • tumor necrosis factor receptor type I
    • tumor necrosis factor-alpha receptor
  • 基因序列:NCBI_Gene: 7132
  • 蛋白序列:UniProtKB: P19438

人 Human TNFRSF1A靶点分子功能(预测)

Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).

操作步骤


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引用文献


  1. Screening of TNFR1 Binding Peptides from Deinagkistrodon acutus Venom through Phage Display 

  2. Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (?)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice 

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