文章目录[隐藏]
TNFRSF1A 分子靶点信息概述
- 分子名:TNFRSF1A, TNF receptor superfamily member 1A
- 基因家族:CD molecules; Tumor necrosis factor receptor superfamily
- 别名:TNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
- 曾用名:TNFR1
- 全称:tumor necrosis factor receptor superfamily, member 1A
TNFRSF1A 分子靶点综述
肿瘤坏死因子受体1(TNFRI),又名肿瘤坏死因子受体超家族成员1A(TNFRSF1A)和CD120a,是肿瘤坏死因子受体超家族的一员。它能激活转录因子NF-κB、介导细胞凋亡和调控炎症。TNFRI基因突变与多发性硬化症风险增加有关。精神分裂症和双相情感障碍患者血清中的TNFRI水平是升高的,且高水平的TNFRI与更严重的精神病症状有关。
TNFRSF1A, TNF receptor superfamily member 1A 分子靶点种属信息
人 Human TNFRSF1A 分子靶点信息
- 分子名:TNFRSF1A, TNF receptor superfamily member 1A
- 别称:
- CD120a
- FPF
- MGC19588
- MS5
- p55
- p55-R
- p60
- TBP1
- TNF-R
- TNF-R-I
- TNF-R1
- TNF-R55
- TNF-RI
- TNFAR
- TNFR-I
- TNFR1
- TNFR1-d2
- TNFR55
- TNFR60
- tumor necrosis factor binding protein 1
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor 1A isoform beta
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1A
- tumor necrosis factor receptor type 1
- tumor necrosis factor receptor type I
- tumor necrosis factor-alpha receptor
- 基因序列:NCBI_Gene: 7132
- 蛋白序列:UniProtKB: P19438
人 Human TNFRSF1A靶点分子功能(预测)
Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).
小鼠 Mouse Tnfrsf1a 分子靶点信息
- 分子名:Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a
- 别称:
- CD120a
- p55
- p55-R
- TNF receptor alpha chain
- TNF-alpha-R1
- TNF-alphaR1
- TNF-R-I
- TNF-R1
- TNF-R55
- TNFalpha-R1
- TNFAR
- Tnfr-2
- Tnfr1
- TNFR60
- TNFRI
- TNFRp55
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor 2
- 基因序列:NCBI_Gene: 21937
- 蛋白序列:
小鼠 Mouse Tnfrsf1a 靶点分子功能(预测)
Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; and semi-lunar valve development. Acts upstream of or within several processes, including defense response to bacterium; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is expressed in several structures, including alimentary system; extraembryonic component; hemolymphoid system; reproductive system; and respiratory system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
大鼠 Rat Tnfrsf1a 分子靶点信息
- 分子名:Tnfrsf1a, TNF receptor superfamily member 1A
- 别称:
- MGC105478
- p55
- p60
- TNF-R1
- TNF-RI
- TNFR-1
- TNFR-I
- Tnfr1
- Tumor necrosis factor receptor
- tumor necrosis factor receptor 1
- tumor necrosis factor receptor superfamily member 1A
- tumor necrosis factor receptor superfamily, member 1a
- tumor necrosis factor receptor type I
- 基因序列:NCBI_Gene: 25625
- 蛋白序列:
大鼠 Rat Tnfrsf1a 靶点分子功能(预测)
Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in several cellular components, including cell surface; membrane raft; and mitochondrion. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).
TNFRSF1A 分子产品列表
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- EK1109
- ELISA试剂盒
Human sTNF RI/TNFRSF1A ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
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- EK1109S
- ELISA标准品
Human sTNF RI/TNFRSF1A Standard (人可溶性肿瘤坏死因子受体1 标准品)
- ¥180.00