EK189S

Human sICAM-1/CD54 Standard (人细胞间粘附分子1 (ICAM-1) 标准品)

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¥180.00

因产品会迭代升级，具体实验步骤请按纸质版说明书操作

  • 分子靶点：ICAM1, BB2, CD54
  • 种属：人 (Human)
  • 试剂盒：EK189
  • 保存：短期4℃保存，长期-20℃保存
  • 运输条件：4℃蓝冰运输

在售SKU:70-EK189S

描述

本产品只包含标准品试剂，如需购买试剂盒请点击下图

商品名

Human sICAM-1/CD54 Standard (人细胞间粘附分子1 (ICAM-1) 标准品)
组分

人细胞间粘附分子1 (ICAM-1)标准品
检测方法

双抗夹心法
样本类型

血清，血浆，细胞培养上清及其他生物学样本
板式

管
保存

短期4℃，长期-20℃保存
运输条件

4℃蓝冰运输

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人sICAM-1抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的sICAM-1与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中sICAM-1的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human sICAM-1/CD54 ELISA Kit (人细胞间粘附分子1 (ICAM-1) ELISA试剂盒) - 标准曲线
标准曲线

分子信息

概述人 ICAM1, BB2, CD54 靶点信息

ICAM1 分子靶点信息概述

  • 分子名：ICAM1, intercellular adhesion molecule 1
  • 基因家族：CD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
  • 别名：BB2; CD54
  • 全称：human rhinovirus receptor

ICAM1 分子靶点综述

细胞间粘附分子1(ICAM-1)也称为CD54，是一个几乎无所不在的跨膜糖蛋白，通常表达于内皮细胞和免疫细胞，对白细胞迁移和活化具有关键作用。它与CD11a/CD18或CD11b/CD18型整合素结合，也会被鼻病毒作为受体利用。可溶性细胞间粘附分子1(sICAM-1)促进血管生成，可作为血管内皮细胞活化或受损的指示剂。它也可作为跨膜ICAM-1抑制剂，介导活性如单核细胞对活化的内皮细胞的黏附以及肿瘤细胞对NK细胞介导的溶解作用的敏感性。监测血清中的sICAM-1表达水平可对多种病理状态提供更加详细的视角，如心血管疾病、II型糖尿病、器官移植障碍、氧化应激、腹部脂肪团、高血压、肝脏疾病和某些恶性肿瘤等。

人 Human ICAM1 分子靶点信息

  • 分子名：ICAM1, intercellular adhesion molecule 1
  • 别称：
    • BB2
    • CD54
    • cell surface glycoprotein P3.58
    • human rhinovirus receptor
    • ICAM-1
    • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    • major group rhinovirus receptor
    • P3.58
  • 基因序列：NCBI_Gene: 3383
  • 蛋白序列：UniProtKB: P05362

人 Human ICAM1靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and negative regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); and lung disease (multiple).

操作步骤

ELISA操作常见问题

血清OR血浆，哪个是ELISA的菜 

ELISA通关必备丨数据篇丨标准曲线不佳 

ELISA通关必备丨操作篇丨常见问题及解决方案 

ELISA通关必备丨操作篇丨溶解与稀释标准品 

ELISA通关必备丨样本篇丨不常见样本 

ELISA通关必备丨样本篇丨常见样本丨细胞 

ELISA通关必备丨如何选择试剂盒 

ELISA通关必备丨基础知识 

真？假？ELISA试剂盒选择要小心 

ELISA常见类型一 | 双抗夹心法，你要的都在这里！ 

ELISA常见类型二 | 竞争法，五分钟搞定！ 

叮！联科向您投递了个ELISA实验操作干货包，请查收~ 

【视频】ELISA实验操作步骤演示视频教程 

ELISA 组织样本的处理—大鼠组织 

【视频】ELISA实验原理与常见问题分析 

查看更多ELISA操作相关问题

引用文献

文章目录[隐藏]


  1. Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways 

  2. Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway 

  3. miR-374b-5p is increased in deep vein thrombosis and negatively targets IL-10 

  4. Plasma exosomal miRNAs involved in endothelial injury in microscopic polyangiitis patients 

  5. Comprehensive Analysis of NAFLD and the Therapeutic Target Identified 

  6. HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury 

  7. Simplified Gambogic Acid Prodrug Nanoparticles to Improve Efficiency and Reduce Toxicity for Clinical Translation Potential 

  8. Procyanidin B2 alleviates oxidized low-density lipoprotein-induced cell injury, inflammation, monocyte chemotaxis, and oxidative stress by inhibiting the nuclear factor kappa-B pathway in human umbilical vein endothelial cells 

  9. LncRNA MALAT1 suppresses monocyte-endothelial cell interactions by targeting miR-30b-5p and enhancing ATG5-mediated autophagy 

  10. The Potential of Bioactive Fish Collagen Oligopeptides against Hydrogen Peroxide-Induced NIH/3T3 and HUVEC Damage: The Involvement of the Mitochondria 

  11. A dual-targeting therapeutic nanobubble for imaging-guided atherosclerosis treatment 

  12. Beneficial Effects of Small-Molecule Oligopeptides Isolated from Panax Ginseng C. A. Meyer on Cellular Fates in Oxidative Stress-Induced Damaged Human Umbilical Vein Endothelial Cells and PC-12 

  13. Innate immune responsive inflammation in development of progressive myopia 

  14. Long-term abuse of caffeine sodium benzoate induces endothelial cells injury and leads to coagulation dysfunction 

  15. miR-147a targets ZEB2 to regulate ox-LDL-induced monocyte adherence to HUVECs, atherosclerotic plaque formation, and stability in atherosclerosis 

  16. 5-epi-ent-Kaurane diterpenoids from the aerial parts of Isodon eriocalyx and their anti-atherosclerotic potential 

  17. Acteoside alleviates asthma by modulating ROS-responsive NF-κB/MAPK signaling pathway 

  18. 血清

    Associations of Serological Biomarkers of Sicam-1, Il-1β, Mif, and Su-Par with 3-Month Mortality in Acute Exacerbation of Idiopathic Pulmonary Fibrosis 

  19. 血清

    Serum vimentin predicts mortality in pediatric severe sepsis: A prospective observational study 

  20. Metabolic Profiling in Association with Vascular Endothelial Cell Dysfunction Following Non-Toxic Cadmium Exposure 

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