Human IL-12 p70 High Sensitivity Standard (人白细胞介素12高敏标准品)
¥280.00
因产品会迭代升级,具体实验步骤请按纸质版说明书操作
- 分子靶点:IL12, IL-12, CLMF
- 种属:人 (Human)
- 试剂盒:EK112HS
- 保存:短期4℃保存,长期-20℃保存
- 运输条件:4℃蓝冰运输
在售SKU:70-EK112HSS, 人, 白介素12, 白介12, IL12, interleukin 12
描述
文章目录[隐藏]
本产品只包含标准品试剂,如需购买试剂盒请点击下图
-
- EK112HS
- 高敏试剂盒
Human IL-12p70 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
商品名 |
Human IL-12p70 High Sensitivity Standard (人白细胞介素12高敏标准品) |
---|---|
组分 |
人 IL-12p70 高敏标准品 |
检测方法 |
双抗夹心法 |
样本类型 |
血清,血浆,细胞培养上清及其他生物学样本 |
板式 |
管 |
保存 |
短期4℃,长期-20℃保存 |
运输条件 |
4℃蓝冰运输 |
检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-12p70抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本,经过孵育,样本中存在的IL-12p70与固相抗体结合。洗涤去除未结合的物质后,加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体,加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后,加入信号增强剂孵育,洗涤去除未结合的物质后,再次加入Streptavidin-HRP。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中IL-12p70的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。
IL12A 分子靶点信息概述
- 分子名:IL12A, interleukin 12A
- 基因家族:Interleukins
- 别名:CLMF; IL-12A; p35; NFSK
- 曾用名:NKSF1
- 全称:nterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation factor 1, p35; interleukin 12, p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; interleukin-12 alpha chain; IL35 subunit
IL12B 分子靶点信息概述
- 分子名:IL12B, interleukin 12B
- 基因家族:Immunoglobulin like domain containing; Interleukins
- 别名:CLMF; IL-12B; NKSF; CLMF2
- 曾用名:NKSF2
- 全称:natural killer cell stimulatory factor-2; cytotoxic lymphocyte maturation factor 2, p40; interleukin 12, p40; natural killer cell stimulatory factor, 40 kD subunit; interleukin-12 beta chain; IL12, subunit p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
IL12B 分子靶点综述
白细胞介素12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人B淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12由4个а螺旋组成,是一个由2种独立基因--- IL-12A (p35)和IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体p40。IL-12参与初始T细胞向Th1细胞分化的过程,作为T细胞刺激因子,它可刺激T细胞的生长及其功能发挥。IL-12具有抗血管生成活性,对自然杀伤细胞和T淋巴细胞活性有重要作用。同样地,IL-12与自身免疫相关。
IL12, interleukin 12 分子靶点种属信息
人 Human IL12A 分子靶点信息
- 分子名:IL12A, interleukin 12A
- 别称:
- CLMF
- CLMF p35
- cytotoxic lymphocyte maturation factor 1, p35
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- IL-12 subunit p35
- IL-12, subunit p35
- IL-12A
- IL35 subunit
- interleukin 12, p35
- interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
- interleukin-12 alpha chain
- interleukin-12 subunit alpha
- natural killer cell stimulatory factor 1, 35 kD subunit
- NF cell stimulatory factor chain 1
- NFSK
- NK cell stimulatory factor chain 1
- NKSF1
- P35
- 基因序列:NCBI_Gene: 3592
- 蛋白序列:UniProtKB: P29459
人 Human IL12A靶点分子功能(预测)
Enables interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Contributes to cytokine activity and growth factor activity. Involved in several processes, including positive regulation of leukocyte mediated cytotoxicity; positive regulation of lymphocyte proliferation; and response to bacterium. Acts upstream of or within negative regulation of protein secretion. Located in extracellular space. Part of interleukin-12 complex. Implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Biomarker of hepatitis C.
人 Human IL12B 分子靶点信息
- 分子名:IL12B, interleukin 12B
- 别称:
- CLMF
- CLMF p40
- CLMF2
- cytotoxic lymphocyte maturation factor 40 kDa subunit
- IL-12 subunit p40
- IL-12B
- IL12, subunit p40
- IMD28
- IMD29
- interleukin 12, p40
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- interleukin-12 beta chain
- interleukin-12 subunit beta
- natural killer cell stimulatory factor, 40 kD subunit
- NK cell stimulatory factor chain 2
- NKSF
- NKSF2
- 基因序列:NCBI_Gene: 3593
- 蛋白序列:UniProtKB: P29460
人 Human IL12B靶点分子功能(预测)
Enables identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte proliferation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of cytokine production. Acts upstream of or within negative regulation of protein secretion. Part of interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Biomarker of anogenital venereal wart.
操作步骤
文章目录[隐藏]
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引用文献
文章目录[隐藏]
- Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome 
- Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes 
- Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis 
- MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites 
- CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study 
- A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism 
- High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients 
- Cell-free miR-17-5p as a diagnostic biomarker for gastric cancer inhibits dendritic cell maturation 
- Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells 
- Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy 
- Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes 
- Comparison of morphology, phenotypes and function between cultured human IL‑4‑DC and IFN‑DC 
- Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study 
- The clinical study on treatment of CD19-directed chimeric antigen receptor-modified T cells in a case of refractory Richter syndrome 
- Follistatin-Like Protein-1 Upregulates Dendritic Cell-Based Immunity in Patients with Nasopharyngeal Carcinoma 
- Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma 
- Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial 
- Infant immune response to hepatitis B vaccine after fetal exposure to telbivudine 
Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome 
Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes 
Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis 
MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites 
CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study 
A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism 
High-Dose Aluminum Exposure Further Alerts Immune Phenotype in Aplastic Anemia Patients 
Cell-free miR-17-5p as a diagnostic biomarker for gastric cancer inhibits dendritic cell maturation 
Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells 
Circulating CD14+CD163+CD206+ M2 Monocytes Are Increased in Patients with Early Stage of Idiopathic Membranous Nephropathy 
Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes 
Comparison of morphology, phenotypes and function between cultured human IL‑4‑DC and IFN‑DC 
Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study 
The clinical study on treatment of CD19-directed chimeric antigen receptor-modified T cells in a case of refractory Richter syndrome 
Follistatin-Like Protein-1 Upregulates Dendritic Cell-Based Immunity in Patients with Nasopharyngeal Carcinoma 
Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3–Targeted Chimeric Antigen Receptor–Engineered T Cells in Hepatocellular Carcinoma 
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial 
Infant immune response to hepatitis B vaccine after fetal exposure to telbivudine 
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