文章目录[隐藏]
- IL12A 分子靶点信息概述
- IL12B 分子靶点信息概述
- IL12B 分子靶点综述
- IL12, interleukin 12 分子靶点种属信息
- IL-12 分子产品列表
- Mouse IL-12/IL-23p40 ELISA Kit检测试剂盒(酶联免疫吸附法)
- Mouse IL-12/IL-23p40 Standard (小鼠 IL-12/IL-23p40 标准品)
- Mouse IL-12p70 High Sensitivity Standard (小鼠白细胞介素12 (IL-12) 高敏 标准品)
- Mouse IL-12p70 Standard (小鼠IL-12p70 标准品)
- Mouse IL-12p70 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- Mouse IL-12p70 ELISA Kit检测试剂盒(酶联免疫吸附法)
- Human IL-12 p70 Standard (人白介素12 p70 标准品)
- Human IL-12p70 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- Human IL-12 p70 High Sensitivity Standard (人白细胞介素12高敏标准品)
- Human IL-12p70 ELISA Kit检测试剂盒(酶联免疫吸附法)
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白细胞介素 12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人 B 淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12 是一个由 2 种独立基因 IL-12A (p35)和 IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体 p40。
IL12A 分子靶点信息概述
- 分子名:IL12A, interleukin 12A
- 基因家族:Interleukins
- 别名:CLMF; IL-12A; p35; NFSK
- 曾用名:NKSF1
- 全称:nterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); natural killer cell stimulatory factor 1, 35 kD subunit; cytotoxic lymphocyte maturation factor 1, p35; interleukin 12, p35; IL-12, subunit p35; NF cell stimulatory factor chain 1; interleukin-12 alpha chain; IL35 subunit
IL12B 分子靶点信息概述
- 分子名:IL12B, interleukin 12B
- 基因家族:Immunoglobulin like domain containing; Interleukins
- 别名:CLMF; IL-12B; NKSF; CLMF2
- 曾用名:NKSF2
- 全称:natural killer cell stimulatory factor-2; cytotoxic lymphocyte maturation factor 2, p40; interleukin 12, p40; natural killer cell stimulatory factor, 40 kD subunit; interleukin-12 beta chain; IL12, subunit p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
IL12B 分子靶点综述
白细胞介素12 (IL-12)由树突状细胞、巨噬细胞、中性粒细胞和人B淋巴母细胞株 (NC-37)在响应抗原刺激时自然产生。IL-12由4个а螺旋组成,是一个由2种独立基因--- IL-12A (p35)和IL-12B (p40)编码形成的异源二聚体细胞因子。蛋白合成之后可形成有生物活性的异源二聚体(p70)和同源二聚体p40。IL-12参与初始T细胞向Th1细胞分化的过程,作为T细胞刺激因子,它可刺激T细胞的生长及其功能发挥。IL-12具有抗血管生成活性,对自然杀伤细胞和T淋巴细胞活性有重要作用。同样地,IL-12与自身免疫相关。
IL12, interleukin 12 分子靶点种属信息
人 Human IL12A 分子靶点信息
- 分子名:IL12A, interleukin 12A
- 别称:
- CLMF
- CLMF p35
- cytotoxic lymphocyte maturation factor 1, p35
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- IL-12 subunit p35
- IL-12, subunit p35
- IL-12A
- IL35 subunit
- interleukin 12, p35
- interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
- interleukin-12 alpha chain
- interleukin-12 subunit alpha
- natural killer cell stimulatory factor 1, 35 kD subunit
- NF cell stimulatory factor chain 1
- NFSK
- NK cell stimulatory factor chain 1
- NKSF1
- P35
- 基因序列:NCBI_Gene: 3592
- 蛋白序列:UniProtKB: P29459
人 Human IL12A靶点分子功能(预测)
Enables interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Contributes to cytokine activity and growth factor activity. Involved in several processes, including positive regulation of leukocyte mediated cytotoxicity; positive regulation of lymphocyte proliferation; and response to bacterium. Acts upstream of or within negative regulation of protein secretion. Located in extracellular space. Part of interleukin-12 complex. Implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Biomarker of hepatitis C.
人 Human IL12B 分子靶点信息
- 分子名:IL12B, interleukin 12B
- 别称:
- CLMF
- CLMF p40
- CLMF2
- cytotoxic lymphocyte maturation factor 40 kDa subunit
- IL-12 subunit p40
- IL-12B
- IL12, subunit p40
- IMD28
- IMD29
- interleukin 12, p40
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- interleukin-12 beta chain
- interleukin-12 subunit beta
- natural killer cell stimulatory factor, 40 kD subunit
- NK cell stimulatory factor chain 2
- NKSF
- NKSF2
- 基因序列:NCBI_Gene: 3593
- 蛋白序列:UniProtKB: P29460
人 Human IL12B靶点分子功能(预测)
Enables identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte proliferation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of cytokine production. Acts upstream of or within negative regulation of protein secretion. Part of interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Biomarker of anogenital venereal wart.
小鼠 Mouse Il12a 分子靶点信息
- 分子名:Il12a, interleukin 12a
- 别称:
- Il-12a
- IL-12p35
- p35
- 基因序列:NCBI_Gene: 16159
- 蛋白序列:
小鼠 Mouse Il12a 靶点分子功能(预测)
Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Involved in positive regulation of T cell proliferation. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of type II interferon production. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).
小鼠 Mouse Il12b 分子靶点信息
- 分子名:Il12b, interleukin 12b
- 别称:
- IL-12 p40
- Il-12b
- Il-12p40
- IL-23 subunit p40
- 基因序列:NCBI_Gene: 16160
- 蛋白序列:
小鼠 Mouse Il12b 靶点分子功能(预测)
Enables identical protein binding activity and interleukin-12 alpha subunit binding activity. Contributes to cytokine activity and cytokine receptor binding activity. Involved in positive regulation of T cell mediated cytotoxicity; positive regulation of T-helper 1 type immune response; and positive regulation of defense response to virus by host. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of interferon-gamma production. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex and interleukin-23 complex. Is expressed in colon. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).
大鼠 Rat Il12a 分子靶点信息
- 分子名:Il12a, interleukin 12A
- 别称:
- CLMF p35
- cytotoxic lymphocyte maturation factor 35 kDa subunit
- IL-12 subunit p35
- IL-12A
- interleukin 12 p35 subunit
- interleukin-12 subunit alpha
- 基因序列:NCBI_Gene: 84405
- 蛋白序列:
大鼠 Rat Il12a 靶点分子功能(预测)
Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface; cytoplasm; and extracellular space. Predicted to be part of interleukin-12 complex. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A).
大鼠 Rat Il12b 分子靶点信息
- 分子名:Il12b, interleukin 12B
- 别称:
- Il12
- Interleukin 12
- interleukin-12 p40
- interleukin-12 p40 precursor
- interleukin-12 subunit beta
- 基因序列:NCBI_Gene: 64546
- 蛋白序列:
大鼠 Rat Il12b 靶点分子功能(预测)
Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).
IL-12 分子产品列表
-
- EK2183
- ELISA试剂盒
Mouse IL-12/IL-23p40 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK212S
- ELISA标准品
Mouse IL-12p70 Standard (小鼠IL-12p70 标准品)
- ¥180.00
-
- EK212HS
- ELISA试剂盒, 高敏试剂盒
Mouse IL-12p70 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
-
- EK212
- ELISA试剂盒
Mouse IL-12p70 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK112S
- ELISA标准品
Human IL-12 p70 Standard (人白介素12 p70 标准品)
- ¥180.00
-
- EK112HS
- ELISA试剂盒, 高敏试剂盒
Human IL-12p70 High Sensitivity ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00
-
- EK112HSS
- ELISA标准品, 高敏试剂盒
Human IL-12 p70 High Sensitivity Standard (人白细胞介素12高敏标准品)
- ¥280.00
-
- EK112
- ELISA试剂盒
Human IL-12p70 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00