Human Fas/TNFRSF6/CD95 Standard (人Fas/TNFRSF6/CD95 标准品)

FAS 分子靶点信息概述

• 分子名：FAS, Fas cell surface death receptor
• 基因家族：CD molecules; Tumor necrosis factor receptor superfamily; Death inducing signaling complex
• 别名：CD95; APO-1
• 曾用名：FAS1; APT1; TNFRSF6
• 全称：TNF receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)

FAS 分子靶点综述

Fas，又名APO-1、CD95或TNFRSF6，是一个可转导凋亡信号的细胞表面受体。它是两种凋亡途径之一，另一种是线粒体途径。一旦结合配体，Fas就会形成死亡诱导信号复合物。相邻细胞表面的膜锚定Fas配体三聚体会导致Fas低聚化。近来的小鼠模型研究表明，Fas促进其肿瘤生长，但是人类癌症基因组学数据库表明Fas可作为肿瘤抑制物。在AOM-DSS诱导的结肠癌和MCA诱导的肉瘤小鼠模型中，结果显示Fas是肿瘤抑制物。另外，Fas还可介导肿瘤特异性细胞毒性T细胞的抗肿瘤细胞毒作用。研究报道，癌症和自身免疫性疾病患者的血清Fas水平是升高的，前者可能来源于肿瘤细胞本身。

人 Human FAS 分子靶点信息

• 分子名：FAS, Fas cell surface death receptor
• 别称：
  • ALPS1A
  • APO-1
  • apo-1 antigen
  • APO-1 cell surface antigen
  • apoptosis antigen 1
  • apoptosis signaling receptor FAS
  • apoptosis-mediating surface antigen FAS
  • APT1
  • CD95
  • CD95 antigen
  • Delta Fas/APO-1/CD95
  • Fas (TNF receptor superfamily, member 6)
  • FAS 827dupA
  • Fas AMA
  • Fas antigen
  • FAS receptor variant 9
  • FAS1
  • FASLG receptor
  • FASTM
  • mutant tumor necrosis receptor superfamily member 6
  • RP11-399O19.9
  • TNF receptor superfamily member 6
  • TNFRSF6
  • tumor necrosis factor receptor superfamily member 6
  • tumor necrosis factor receptor superfamily, member 6
• 基因序列：NCBI_Gene: 355
• 蛋白序列：UniProtKB: P25445

人 Human FAS靶点分子功能（预测）

Enables calmodulin binding activity; identical protein binding activity; and kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular protein metabolic process; and regulation of signal transduction. Acts upstream of or within apoptotic process. Located in several cellular components, including cell surface; membrane raft; and nuclear body. Part of CD95 death-inducing signaling complex. Implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and neurodegenerative disease (multiple).