EK1F01S

Human Fas/TNFRSF6/CD95 Standard (人Fas/TNFRSF6/CD95 标准品)

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¥280.00

因产品会迭代升级,具体实验步骤请按纸质版说明书操作

  • 分子靶点:FAS, TNFRSF6, CD95, APO-1
  • 种属:人 (Human)
  • 试剂盒:EK1F01
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1F01S


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human Fas/TNFRSF6/CD95 Standard (人Fas/TNFRSF6/CD95 标准品)

组分

人Fas/TNFRSF6/CD95冻干标准品

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人Fas抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的Fas与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中Fas的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human Fas/TNFRSF6/CD95 ELISA Kit (人Fas/TNFRSF6/CD95 ELISA试剂盒) - 标准曲线
标准曲线

分子信息

概述人 FAS, TNFRSF6, CD95, APO-1 靶点信息

FAS 分子靶点信息概述

  • 分子名:FAS, Fas cell surface death receptor
  • 基因家族:CD molecules; Tumor necrosis factor receptor superfamily; Death inducing signaling complex
  • 别名:CD95; APO-1
  • 曾用名:FAS1; APT1; TNFRSF6
  • 全称:TNF receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)

FAS 分子靶点综述

Fas,又名APO-1、CD95或TNFRSF6,是一个可转导凋亡信号的细胞表面受体。它是两种凋亡途径之一,另一种是线粒体途径。一旦结合配体,Fas就会形成死亡诱导信号复合物。相邻细胞表面的膜锚定Fas配体三聚体会导致Fas低聚化。近来的小鼠模型研究表明,Fas促进其肿瘤生长,但是人类癌症基因组学数据库表明Fas可作为肿瘤抑制物。在AOM-DSS诱导的结肠癌和MCA诱导的肉瘤小鼠模型中,结果显示Fas是肿瘤抑制物。另外,Fas还可介导肿瘤特异性细胞毒性T细胞的抗肿瘤细胞毒作用。研究报道,癌症和自身免疫性疾病患者的血清Fas水平是升高的,前者可能来源于肿瘤细胞本身。

人 Human FAS 分子靶点信息

  • 分子名:FAS, Fas cell surface death receptor
  • 别称:
    • ALPS1A
    • APO-1
    • apo-1 antigen
    • APO-1 cell surface antigen
    • apoptosis antigen 1
    • apoptosis signaling receptor FAS
    • apoptosis-mediating surface antigen FAS
    • APT1
    • CD95
    • CD95 antigen
    • Delta Fas/APO-1/CD95
    • Fas (TNF receptor superfamily, member 6)
    • FAS 827dupA
    • Fas AMA
    • Fas antigen
    • FAS receptor variant 9
    • FAS1
    • FASLG receptor
    • FASTM
    • mutant tumor necrosis receptor superfamily member 6
    • RP11-399O19.9
    • TNF receptor superfamily member 6
    • TNFRSF6
    • tumor necrosis factor receptor superfamily member 6
    • tumor necrosis factor receptor superfamily, member 6
  • 基因序列:NCBI_Gene: 355
  • 蛋白序列:UniProtKB: P25445

人 Human FAS靶点分子功能(预测)

Enables calmodulin binding activity; identical protein binding activity; and kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular protein metabolic process; and regulation of signal transduction. Acts upstream of or within apoptotic process. Located in several cellular components, including cell surface; membrane raft; and nuclear body. Part of CD95 death-inducing signaling complex. Implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and neurodegenerative disease (multiple).

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