FAS 靶点信息

FAS 分子靶点信息概述

  • 分子名：FAS, Fas cell surface death receptor
  • 基因家族：CD molecules; Tumor necrosis factor receptor superfamily; Death inducing signaling complex
  • 别名：CD95; APO-1
  • 曾用名：FAS1; APT1; TNFRSF6
  • 全称：TNF receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6)

FAS 分子靶点综述

Fas，又名APO-1、CD95或TNFRSF6，是一个可转导凋亡信号的细胞表面受体。它是两种凋亡途径之一，另一种是线粒体途径。一旦结合配体，Fas就会形成死亡诱导信号复合物。相邻细胞表面的膜锚定Fas配体三聚体会导致Fas低聚化。近来的小鼠模型研究表明，Fas促进其肿瘤生长，但是人类癌症基因组学数据库表明Fas可作为肿瘤抑制物。在AOM-DSS诱导的结肠癌和MCA诱导的肉瘤小鼠模型中，结果显示Fas是肿瘤抑制物。另外，Fas还可介导肿瘤特异性细胞毒性T细胞的抗肿瘤细胞毒作用。研究报道，癌症和自身免疫性疾病患者的血清Fas水平是升高的，前者可能来源于肿瘤细胞本身。

FAS, Fas cell surface death receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FAS 分子靶点信息

  • 分子名：FAS, Fas cell surface death receptor
  • 别称：
    • ALPS1A
    • APO-1
    • apo-1 antigen
    • APO-1 cell surface antigen
    • apoptosis antigen 1
    • apoptosis signaling receptor FAS
    • apoptosis-mediating surface antigen FAS
    • APT1
    • CD95
    • CD95 antigen
    • Delta Fas/APO-1/CD95
    • Fas (TNF receptor superfamily, member 6)
    • FAS 827dupA
    • Fas AMA
    • Fas antigen
    • FAS receptor variant 9
    • FAS1
    • FASLG receptor
    • FASTM
    • mutant tumor necrosis receptor superfamily member 6
    • RP11-399O19.9
    • TNF receptor superfamily member 6
    • TNFRSF6
    • tumor necrosis factor receptor superfamily member 6
    • tumor necrosis factor receptor superfamily, member 6
  • 基因序列：NCBI_Gene: 355
  • 蛋白序列：UniProtKB: P25445

人 Human FAS靶点分子功能（预测）

Enables calmodulin binding activity; identical protein binding activity; and kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular protein metabolic process; and regulation of signal transduction. Acts upstream of or within apoptotic process. Located in several cellular components, including cell surface; membrane raft; and nuclear body. Part of CD95 death-inducing signaling complex. Implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and neurodegenerative disease (multiple).

小鼠 Mouse Fas 分子靶点信息

小鼠 Mouse Fas 靶点分子功能（预测）

Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).

大鼠 Rat Fas 分子靶点信息

  • 分子名：Fas, Fas cell surface death receptor
  • 别称：
    • apo-1 antigen
    • apoptosis-mediating surface antigen FAS
    • CD95 antigen
    • Fas (TNF receptor superfamily, member 6)
    • Fas antigen (ATP1)
    • Fas receptor
    • FASLG receptor
    • Tnfrsf6
    • tumor necrosis factor receptor superfamily member 6
    • Tumor necrosis factor receptor superfamily, member 6
  • 基因序列：NCBI_Gene: 246097
  • 蛋白序列：

大鼠 Rat Fas 靶点分子功能（预测）

Enables protease binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and nervous system development. Located in several cellular components, including apical dendrite; apical plasma membrane; and sarcolemma. Part of CD95 death-inducing signaling complex. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor).

FAS 分子产品列表

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