Human ErbB2/HER2/CD340 Standard (人表皮生长因子受体2 (HER2) 标准品)

ERBB2 分子靶点信息概述

• 分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
• 基因家族：CD molecules; Minor histocompatibility antigens; Erb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
• 别名：NEU; HER-2; CD340; HER2
• 曾用名：NGL
• 全称：neuro/glioblastoma derived oncogene homolog; human epidermal growth factor receptor 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

ERBB2 分子靶点综述

ErbB2在人类中由ERBB2基因编码，通常也称之为原癌基因人类表皮生长因子受体2(HER2)或CD340。HER2由胞外配体结合域、跨膜结构域和胞内结构域3部分组成，这些结构域可以和大量信号分子相互作用，体现出配体依赖和非配体依赖性活性。扩增或过表达该致癌基因对某些不良类型的乳腺癌发展有重要作用。近几年来，该蛋白已成为近30%乳腺癌患者生物治疗的一个重要靶点。

人 Human ERBB2 分子靶点信息

• 分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
• 别称：
  • c-erb B2/neu protein
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • herstatin
  • human epidermal growth factor receptor 2
  • metastatic lymph node gene 19 protein
  • MLN 19
  • NEU
  • neuro/glioblastoma derived oncogene homolog
  • neuroblastoma/glioblastoma derived oncogene homolog
  • NGL
  • p185erbB2
  • proto-oncogene c-ErbB-2
  • proto-oncogene Neu
  • receptor tyrosine-protein kinase erbB-2
  • TKR1
  • tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • VSCN2
• 基因序列：NCBI_Gene: 2064
• 蛋白序列：UniProtKB: P04626

人 Human ERBB2靶点分子功能（预测）

Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; protein phosphorylation; and regulation of MAPK cascade. Acts upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; cytosol; and endosome membrane. Part of ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).