ERBB2 靶点信息

ERBB2 分子靶点信息概述

  • 分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
  • 基因家族：CD molecules; Minor histocompatibility antigens; Erb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
  • 别名：NEU; HER-2; CD340; HER2
  • 曾用名：NGL
  • 全称：neuro/glioblastoma derived oncogene homolog; human epidermal growth factor receptor 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

ERBB2 分子靶点综述

ErbB2在人类中由ERBB2基因编码，通常也称之为原癌基因人类表皮生长因子受体2(HER2)或CD340。HER2由胞外配体结合域、跨膜结构域和胞内结构域3部分组成，这些结构域可以和大量信号分子相互作用，体现出配体依赖和非配体依赖性活性。扩增或过表达该致癌基因对某些不良类型的乳腺癌发展有重要作用。近几年来，该蛋白已成为近30%乳腺癌患者生物治疗的一个重要靶点。

ERBB2, erb-b2 receptor tyrosine kinase 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ERBB2 分子靶点信息

  • 分子名：ERBB2, erb-b2 receptor tyrosine kinase 2
  • 别称：
    • c-erb B2/neu protein
    • CD340
    • HER-2
    • HER-2/neu
    • HER2
    • herstatin
    • human epidermal growth factor receptor 2
    • metastatic lymph node gene 19 protein
    • MLN 19
    • NEU
    • neuro/glioblastoma derived oncogene homolog
    • neuroblastoma/glioblastoma derived oncogene homolog
    • NGL
    • p185erbB2
    • proto-oncogene c-ErbB-2
    • proto-oncogene Neu
    • receptor tyrosine-protein kinase erbB-2
    • TKR1
    • tyrosine kinase-type cell surface receptor HER2
    • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
    • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
    • v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    • VSCN2
  • 基因序列：NCBI_Gene: 2064
  • 蛋白序列：UniProtKB: P04626

人 Human ERBB2靶点分子功能（预测）

Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; protein phosphorylation; and regulation of MAPK cascade. Acts upstream of or within cell surface receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; cytosol; and endosome membrane. Part of ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).

小鼠 Mouse Erbb2 分子靶点信息

小鼠 Mouse Erbb2 靶点分子功能（预测）

Predicted to enable several functions, including ErbB-3 class receptor binding activity; Hsp90 protein binding activity; and enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive regulation of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).

大鼠 Rat Erbb2 分子靶点信息

  • 分子名：Erbb2, erb-b2 receptor tyrosine kinase 2
  • 别称：
    • Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
    • C-erbB-2
    • epidermal growth factor receptor-related protein
    • HER2/neu
    • LOC102552659
    • neu
    • NEU proto-oncogene
    • p185erbB2
    • p185neu
    • proto-oncogene c-ErbB-2
    • proto-oncogene NEU
    • receptor tyrosine-protein kinase erbB-2
    • receptor tyrosine-protein kinase erbB-2-like
    • v-erb-b2 avian erythroblastic leukemia viral oncogene 2
    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • 基因序列：NCBI_Gene: 24337
  • 蛋白序列：

大鼠 Rat Erbb2 靶点分子功能（预测）

Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and microvillus. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).

ERBB2 分子产品列表

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