Human EphB6/Eph Receptor B6 Standard (人酪氨酸蛋白激酶受体B6 标准品)

EPHB6 分子靶点信息概述

• 分子名：EPHB6, EPH receptor B6
• 基因家族：Sterile alpha motif domain containing; EPH receptors
• 别名：HEP
• 全称：EphB6

EPHB6 分子靶点综述

根据结构和序列关系，Ephrins可分为ephrin-A(EFNA)类和ephrin-B(EFNB)类。Ephrin受体是受体酪氨酸激酶(RTK)家族中最大的亚群。EphrinB型受体6(EphB6)是一个不寻常的Eph受体，由于其激酶结构域的改变导致它缺少催化能力。EphB6可正向、负向地调节细胞粘附和迁移。另外，Ephrin-B2可能是EphB6受体的一个生理配体。在一些肿瘤类型中，包括乳腺癌，转移活性的增加与EphB6受体表达量降低有关，这说明EphB6有可能作为癌症侵袭的抑制物。EphB6通过c-Cbl依赖的信号、形态变化和细胞附着来抑制癌症侵袭，表明EphB6可能是一个有用的预后指标和治疗靶点。

人 Human EPHB6 分子靶点信息

• 分子名：EPHB6, EPH receptor B6
• 别称：
  • ephrin type-B receptor 6
  • HEP
  • human kinase-defective Eph-family receptor protein
  • MGC129910
  • MGC129911
  • tyrosine-protein kinase-defective receptor EPH-6
• 基因序列：NCBI_Gene: 2051
• 蛋白序列：UniProtKB: O15197

人 Human EPHB6靶点分子功能（预测）

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cytosol; extracellular region; and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane.