EPHB6 靶点信息

EPHB6 分子靶点信息概述

  • 分子名：EPHB6, EPH receptor B6
  • 基因家族：Sterile alpha motif domain containing; EPH receptors
  • 别名：HEP
  • 全称：EphB6

EPHB6 分子靶点综述

根据结构和序列关系，Ephrins可分为ephrin-A(EFNA)类和ephrin-B(EFNB)类。Ephrin受体是受体酪氨酸激酶(RTK)家族中最大的亚群。EphrinB型受体6(EphB6)是一个不寻常的Eph受体，由于其激酶结构域的改变导致它缺少催化能力。EphB6可正向、负向地调节细胞粘附和迁移。另外，Ephrin-B2可能是EphB6受体的一个生理配体。在一些肿瘤类型中，包括乳腺癌，转移活性的增加与EphB6受体表达量降低有关，这说明EphB6有可能作为癌症侵袭的抑制物。EphB6通过c-Cbl依赖的信号、形态变化和细胞附着来抑制癌症侵袭，表明EphB6可能是一个有用的预后指标和治疗靶点。

EPHB6, EPH receptor B6 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EPHB6 分子靶点信息

  • 分子名：EPHB6, EPH receptor B6
  • 别称：
    • ephrin type-B receptor 6
    • HEP
    • human kinase-defective Eph-family receptor protein
    • MGC129910
    • MGC129911
    • tyrosine-protein kinase-defective receptor EPH-6
  • 基因序列：NCBI_Gene: 2051
  • 蛋白序列：UniProtKB: O15197

人 Human EPHB6靶点分子功能（预测）

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cytosol; extracellular region; and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane.

小鼠 Mouse Ephb6 分子靶点信息

小鼠 Mouse Ephb6 靶点分子功能（预测）

Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6).

大鼠 Rat Ephb6 分子靶点信息

  • 分子名：Ephb6, Eph receptor B6
  • 别称：
    • ephrin type-B receptor 6
    • LOC102554290
    • LOC312275
    • serine/arginine repetitive matrix protein 2-like
    • tyrosine-protein kinase-defective receptor EPH-6
  • 基因序列：NCBI_Gene: 312275
  • 蛋白序列：UniProtKB: P0C0K7

大鼠 Rat Ephb6 靶点分子功能（预测）

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHB6 (EPH receptor B6).

EPHB6 分子产品列表

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