EK1130S

Human CCL11/Eotaxin Standard (人趋化因子配体11 标准品)

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¥280.00

因产品会迭代升级,具体实验步骤请按纸质版说明书操作

  • 分子靶点:CCL11, Eotaxin, SCYA11
  • 种属:人 (Human)
  • 试剂盒:EK1130
  • 保存:短期4℃保存,长期-20℃保存
  • 运输条件:4℃蓝冰运输

在售SKU:70-EK1130S


描述

本产品只包含标准品试剂,如需购买试剂盒请点击下图

商品名

Human CCL11/Eotaxin Standard (人趋化因子配体11 标准品)

组分

人CCL11/EotaxinA 标准品

检测方法

双抗夹心法

样本类型

血清,血浆,细胞培养上清及其他生物学样本

板式

保存

短期4℃,长期-20℃保存

运输条件

4℃蓝冰运输

检测原理:本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人CCL11抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体,经过孵育,样本中存在的CCL11与固相抗体和检测抗体结合。洗涤去除未结合的物质后,加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后,加入显色底物TMB,避光显色。颜色反应的深浅与样本中CCL11的浓度成正比。加入终止液终止反应,在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human CCL11/Eotaxin ELISA Kit (人趋化因子配体11 ELISA试剂盒) - 标准曲线
标准曲线

分子信息

概述人 CCL11, Eotaxin, SCYA11 靶点信息

CCL11 分子靶点信息概述

  • 分子名:CCL11, C-C motif chemokine ligand 11
  • 基因家族:Chemokine ligands
  • 别名:eotaxin; MGC22554
  • 曾用名:SCYA11
  • 全称:eotaxin-1; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); chemokine (C-C motif) ligand 11

CCL11 分子靶点综述

趋化因子配体11(CCL11)也称为嗜酸性粒细胞趋化因子(Eotaxin),是CC趋化因子家族中的小分子量细胞因子。Eotaxin通过诱导嗜酸性粒细胞的趋化性进行选择性招募,因此参与变态反应。Eotaxin在人和小鼠血浆中的表达升高与其衰老有关。相比于曾经吸食大麻者和从未吸食大麻者,目前仍在吸食大麻者的血浆中含有更高浓度的Eotaxin。精神分裂者体内的Eotaxin浓度也更高,而大麻正是已知的精神分裂症诱导剂。

人 Human CCL11 分子靶点信息

  • 分子名:CCL11, C-C motif chemokine ligand 11
  • 别称:
    • C-C motif chemokine 11
    • chemokine (C-C motif) ligand 11
    • eosinophil chemotactic protein
    • eotaxin
    • eotaxin-1
    • MGC22554
    • SCYA11
    • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
    • small-inducible cytokine A11
  • 基因序列:NCBI_Gene: 6356
  • 蛋白序列:UniProtKB: P51671

人 Human CCL11靶点分子功能(预测)

Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.

操作步骤

ELISA操作常见问题

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引用文献


  1. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis 

  2. Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples 

  3. Identification of Robust Biomarkers for Early Predicting Efficacy of Subcutaneous Immunotherapy in Children With House Dust Mite-Induced Allergic Rhinitis by Multiple Cytokine Profiling 

  4. Knockdown of lncRNA ANRIL suppresses the production of inflammatory cytokines and mucin 5AC in nasal epithelial cells via the miR-15a-5p/JAK2 axis 

  5. NAMPT/SIRT1 Expression Levels in White Blood Cells Differentiate the Different Rheumatoid Arthritis Subsets: An Inspiration from Traditional Chinese Medicine 

  6. Acteoside alleviates asthma by modulating ROS-responsive NF-κB/MAPK signaling pathway 

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