CCL11 靶点信息

CCL11 分子靶点信息概述

  • 分子名：CCL11, C-C motif chemokine ligand 11
  • 基因家族：Chemokine ligands
  • 别名：eotaxin; MGC22554
  • 曾用名：SCYA11
  • 全称：eotaxin-1; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); chemokine (C-C motif) ligand 11

CCL11 分子靶点综述

趋化因子配体11(CCL11)也称为嗜酸性粒细胞趋化因子(Eotaxin)，是CC趋化因子家族中的小分子量细胞因子。Eotaxin通过诱导嗜酸性粒细胞的趋化性进行选择性招募，因此参与变态反应。Eotaxin在人和小鼠血浆中的表达升高与其衰老有关。相比于曾经吸食大麻者和从未吸食大麻者，目前仍在吸食大麻者的血浆中含有更高浓度的Eotaxin。精神分裂者体内的Eotaxin浓度也更高，而大麻正是已知的精神分裂症诱导剂。

CCL11, C-C motif chemokine ligand 11 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CCL11 分子靶点信息

  • 分子名：CCL11, C-C motif chemokine ligand 11
  • 别称：
    • C-C motif chemokine 11
    • chemokine (C-C motif) ligand 11
    • eosinophil chemotactic protein
    • eotaxin
    • eotaxin-1
    • MGC22554
    • SCYA11
    • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
    • small-inducible cytokine A11
  • 基因序列：NCBI_Gene: 6356
  • 蛋白序列：UniProtKB: P51671

人 Human CCL11靶点分子功能（预测）

Enables CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular region. Implicated in asthma; human immunodeficiency virus infectious disease; and hyperglycemia. Biomarker of several diseases, including cystic fibrosis; hyperglycemia; lung disease (multiple); nephrotic syndrome type 1; and ureteral obstruction.

小鼠 Mouse Ccl11 分子靶点信息

  • 分子名：Ccl11, chemokine (C-C motif) ligand 11
  • 别称：
    • eotaxin
    • Scya11
    • small inducible cytokine A11
  • 基因序列：NCBI_Gene: 20292
  • 蛋白序列：

小鼠 Mouse Ccl11 靶点分子功能（预测）

Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11).

大鼠 Rat Ccl11 分子靶点信息

  • 分子名：Ccl11, C-C motif chemokine ligand 11
  • 别称：
    • C-C motif chemokine 11
    • chemokine (C-C motif) ligand 11
    • eosinophil chemotactic protein
    • eotaxin
    • Scya11
    • small inducible cytokine A11
    • small inducible cytokine subfamily A11
    • small-inducible cytokine A11
  • 基因序列：NCBI_Gene: 29397
  • 蛋白序列：UniProtKB: P97545

大鼠 Rat Ccl11 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including ERK1 and ERK2 cascade; leukocyte chemotaxis; and response to interleukin-13. Located in extracellular space. Used to study allergic rhinitis; asthma; pleurisy; and pneumonia. Biomarker of several diseases, including allergic conjunctivitis; pneumonia; prostatitis; rhinitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11).

CCL11 分子产品列表

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