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F41011b02

Anti-Human/Mouse CD11b, PE (Clone: M1/70) 流式抗体 检测试剂

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¥680.00

  • 分子靶点：CD11B, MAC-1, ITGAM, CR3A
  • 种属：人 (Human); 小鼠 (Mouse)
  • 标记：PE
  • 亚型：Rat IgG2a, κ
  • 克隆号：M1/70

在售SKU, F41011b02, 70-F41011b02-50, 70-F41011b02-100, 70-F41011b02-25


 100T

F41011b02-100
-+

描述

商品名

Anti-Human/Mouse CD11b, PE (Clone: M1/70) 检测试剂
靶点

CD11B, MAC-1, ITGAM, CR3A
标记

PE
仪器

适用488nm, 532nm, 561nm激光器的流式细胞仪
亚型

Rat IgG2a, κ
克隆号

M1/70
推荐应用

流式检测
用量

5 μL /Test
纯化

亲和层析
储存液

含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件

2 - 8℃避光，切勿冻存

结果示例

Anti-Human/Mouse CD11b, PE (Clone: M1/70) 流式抗体 检测试剂 - 结果示例图片Anti-Human/Mouse CD11b, PE (Clone: M1/70) 流式抗体 检测试剂 - 结果示例图片
结果示例

图 - 人外周血染色，左图为Rat IgG2a, κ Isotype control, PE的结果，右图为Anti-Human/Mouse CD11b, PE的结果。以淋巴细胞、粒细胞和单核细胞设门进行分析

分子信息

概述人 Human ITGAM 分子靶点信息小鼠 Mouse Itgam 分子靶点信息

ITGAM 分子靶点信息概述

  • 分子名：ITGAM, integrin subunit alpha M
  • 基因家族：CD molecules; Integrin alpha subunits; Complement system regulators and receptors
  • 别名：MAC-1; CD11b
  • 曾用名：CR3A; CD11B
  • 全称：complement component 3 receptor 3 subunit; macrophage-1 antigen alpha subunit; integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide); integrin, alpha M (complement component 3 receptor 3 subunit)

ITGAM 分子靶点综述

整合素αM（ITGAM）是一种形成巨噬细胞抗原（Mac-1）或补体受体3（CR3）的蛋白亚单位。ITGAM又被称为CR3A和分化抗原簇分子11B（CD11b）。CD11b是一种常见的髓系标志物，在急性髓系白血病中有50%的阳性表达率。CD117和CD11b共同检测有助于从恢复良性增殖（CD117阴性表达，CD11b阳性表达）的病例中区分出急性早幼粒细胞白血病（CD11b阴性表达）。

人 Human ITGAM 分子靶点信息

  • 分子名：ITGAM, integrin subunit alpha M
  • 别称：
    • antigen CD11b (p170)
    • CD11 antigen-like family member B
    • CD11B
    • cell surface glycoprotein MAC-1 subunit alpha
    • complement component 3 receptor 3 subunit
    • CR-3 alpha chain
    • CR3A
    • integrin alpha-M
    • integrin, alpha M (complement component 3 receptor 3 subunit)
    • integrin, alpha M (complement component receptor 3, alpha)
    • leukocyte adhesion receptor MO1
    • MAC-1
    • MAC1A
    • macrophage antigen alpha polypeptide
    • macrophage-1 antigen alpha subunit
    • MGC117044
    • MO1A
    • neutrophil adherence receptor alpha-M subunit
    • SLEB6
  • 基因序列：NCBI_Gene: 3684
  • 蛋白序列：UniProtKB: P11215

人 Human ITGAM靶点分子功能（预测）

Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.

小鼠 Mouse Itgam 分子靶点信息

  • 分子名：Itgam, integrin alpha M
  • 别称：
    • Cd11b
    • CD11B (p170)
    • CD11b/CD18
    • complement component receptor 3 alpha
    • complement receptor type 3
    • CR3
    • F730045J24Rik
    • Ly-40
    • lymphocyte antigen 40
    • Mac-1
    • Mac-1 alpha
    • Mac-1a
    • macrophage antigen alpha chain (integrin)
    • RIKEN cDNA F730045J24 gene
  • 基因序列：NCBI_Gene: 16409
  • 蛋白序列：

小鼠 Mouse Itgam 靶点分子功能（预测）

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).

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